单指数、双指数及拉伸指数模型扩散加权成像参数诊断子宫内膜癌

发布时间：2018-08-23 11:49

【摘要】：目的探讨单指数、双指数及拉伸指数模型扩散加权成像(DWI)各参数在诊断子宫内膜癌中的价值,为子宫内膜癌的诊断提供新的思路。资料与方法回顾性分析28例子宫内膜癌患者和24例子宫内膜正常患者的体素内不相干运动成像资料,分别测量子宫内膜癌组织和正常子宫内膜组织的单指数模型、双指数模型及拉伸指数模型参数,包括标准表观扩散系数(ADC-stand)、慢速表观扩散系数(ADC-slow)、快速表观扩散系数(ADC-fast)、灌注分数(f)、扩散分布指数(DDC)和扩散异质性指数(α)。采用受试者工作特性(ROC)曲线评价各参数值的阈值及诊断效能,分析两组间各参数值的差异以及同组间各参数值的相关性。结果子宫内膜癌组的ADC-stand、ADC-slow、f、DDC及α值均低于子宫内膜正常组,差异均有统计学意义(P0.05),ADC-fast值差异无统计学意义(P0.05);ADC-stand和ADCslow的ROC曲线下面积分别为0.949和0.911,阈值分别为1.245×10-3 mm2/s、0.998×10-3 mm2/s。子宫内膜癌组的ADC-stand与ADC-slow、DDC值均呈正相关(r=0.787、0.880,P0.05),且ADC-slow值均低于ADC-stand值(P0.05)。结论单指数、双指数及拉伸指数模型部分参数的差异能够为子宫内膜癌的诊断提供新的思路。
[Abstract]:Objective to explore the value of (DWI) parameters of single index, double index and stretch index in the diagnosis of endometrial carcinoma, and to provide a new idea for the diagnosis of endometrial carcinoma. Materials and methods the imaging data of 28 cases of endometrial carcinoma and 24 cases of normal endometrium were analyzed retrospectively, and the single index model of endometrial carcinoma and normal endometrial tissue were measured, respectively. The parameters of double exponential model and tensile index model include standard apparent diffusion coefficient (ADC-stand), slow apparent diffusion coefficient (ADC-slow), fast apparent diffusion coefficient (ADC-fast), perfusion fraction (f), diffusion distribution index (DDC) and diffusion heterogeneity index (伪). The threshold value and diagnostic efficiency of each parameter value were evaluated by using the (ROC) curve of the operating characteristics of the subjects, and the difference of each parameter value between the two groups and the correlation between each parameter value of the same group were analyzed. Results the values of DDC and 伪 in endometrial carcinoma group were significantly lower than those in normal endometrium group (P0.05). The area under ROC curve of ADC-stand and ADCslow were 0.949 and 0.911 respectively, and the threshold value was 1.245 脳 10-3 mm ~ (2) / s ~ (0.998 脳 10 ~ (-3) mm ~ (-2 / s) respectively. There was a positive correlation between ADC-stand and ADC-slow DDC in endometrial carcinoma group (P 0.05), and the ADC-slow value was lower than ADC-stand value (P0.05). Conclusion the difference of some parameters of single index, double index and stretch index model can provide a new idea for the diagnosis of endometrial carcinoma.
【作者单位】：新乡医学院第一附属医院核磁共振科;
【基金】：河南省科技攻关计划项目(201503137)
【分类号】：R445.2;R737.33

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