HNL、PCT及CRP在急性细菌感染中的诊断价值研究

发布时间：2018-09-04 16:20

【摘要】：目的研究中性粒细胞载脂蛋白(HNL)、降钙素原(PCT)及C反应蛋白(CRP)在急性细菌感染中的诊断价值。方法选取2015年6-12月间住院急性感染性疾病患者350例,其中细菌性感染的患者184例(细菌组)、病毒性感染的患者166例(病毒组)。选取同期接受健康体格检查的职工或在校学生作为对照组,共155例。根据酶联免疫法、双抗体夹心层析、免疫比浊法等原理分别定量检测所有人员血清中HNL、PCT及CRP值,并分析其实际诊断价值。结果发现细菌组PCT、HNL及CRP分别为(2.41±1.23)ng/mL、(232.54±101.23)ng/mL及(55.14±38.47)mg/L,均显著高于病毒组及对照组水平,且检测出的HNL水平升高最为显著,差异有统计学意义(P0.05)。同时发现细菌组PCT、HNL及CRP的阳性率分别为82.06%、94.02%及70.65%,远远超出病毒组和对照组,且HNL的阳性率最高,差异有统计学意义(P0.05)。而后2组间比较,差异无统计学意义(P0.05)。结论 HNL、PCT及CRP对细菌感染较为敏感,鉴别诊断能力较强,其中以HNL升高最为显著,特异性强、准确率高,可为早期诊断提供重要参考依据。
[Abstract]:Objective To study the diagnostic value of neutrophil apolipoprotein (HNL), procalcitonin (PCT) and C-reactive protein (CRP) in acute bacterial infections.Methods 350 patients with acute infectious diseases were selected from June to December 2015, including 184 patients with bacterial infection (bacterial group) and 166 patients with viral infection (viral group). The serum levels of HNL, PCT and CRP were measured quantitatively by enzyme-linked immunoassay, double antibody sandwich chromatography and immunoturbidimetric assay. The diagnostic value of PCT, HNL and CRP in bacterial group was analyzed. The results showed that the values of PCT, HNL and CRP in bacterial group were (2.41 + 1.23) ng/mL, (232.54 + 101) ng/mL, respectively. The positive rates of PCT, HNL and CRP in bacterial group were 82.06%, 94.02% and 70.65% respectively, which were much higher than those in viral group and control group. The positive rate of HNL was the highest, and the difference was unified. Conclusion HNL, PCT and CRP are more sensitive to bacterial infection and have a stronger ability of differential diagnosis, among which HNL is the most significant, specific and accurate, which can provide an important reference for early diagnosis.
【作者单位】：中国人民解放军第九四医院检验科;第三军医大学附属第一医院检验科;
【分类号】：R51;R446.6

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