血清IL-34水平与SLE疾病活动度关系的研究
发布时间：2018-09-18 07:24
【摘要】：目的:检测系统性红斑狼疮(Systemic lupus erythematosus,SLE)患者血清白细胞介素(Interleukin,IL)-34水平,并进一步探讨IL-34与临床和实验室指标及SLE疾病活动度的关系。方法:采用酶联免疫吸附试验(Enzyme-linked immunosorbent assay,ELISA)测定78例SLE组及53名正常对照组血清IL-34水平,SLE组与正常组血清IL-34水平分析采用曼-惠特尼U检验(Mann-Whitney U test)。结果:与正常对照相比,SLE组血清IL-34水平明显高于正常对照组[(Median,128.9 pg/ml)vs(Median,52.4 pg/ml),P0.001],差异有统计学意义。IL-34水平与SLE疾病活动度、双链DNA抗体(anti-double stranded DNA antibody,anti-ds DNA)滴度、C反应蛋白(C-reactive protein,CRP)呈正相关,与C3水平呈负相关。结论:血清IL-34可能成为SLE的一血清标志物,因其在SLE患者中升高,且与疾病活动度相关。
[Abstract]:Objective: to detect the level of serum interleukin (Interleukin,IL)-34 in patients with systemic lupus erythematosus (Systemic lupus erythematosus,SLE) and to explore the relationship between IL-34 and clinical and laboratory indexes and SLE disease activity. Methods: serum IL-34 levels were measured by enzyme linked immunosorbent assay (Enzyme-linked immunosorbent assay,ELISA) in 78 patients with SLE and 53 normal controls. The serum IL-34 levels were analyzed by Mann-Whitney U test). U test. Results: compared with the normal controls, the serum IL-34 level in the patients with SLE was significantly higher than that in the normal controls [(Median,128.9 pg/ml) vs (Median,52.4 pg/ml) / P0.001]. There was a positive correlation between the level of IL-34 and the disease activity of SLE, and the titer of double-stranded DNA antibody (anti-double stranded DNA antibody,anti-ds DNA) and C-reactive protein (C-reactive protein,CRP). There was a negative correlation with C3 level. Conclusion: serum IL-34 may be a serum marker of SLE because it is increased in SLE patients and correlated with disease activity.
【作者单位】： 重庆医科大学附属第一医院检验科;
【分类号】：R446.6;R593.241
，
本文编号：2247205
[Abstract]:Objective: to detect the level of serum interleukin (Interleukin,IL)-34 in patients with systemic lupus erythematosus (Systemic lupus erythematosus,SLE) and to explore the relationship between IL-34 and clinical and laboratory indexes and SLE disease activity. Methods: serum IL-34 levels were measured by enzyme linked immunosorbent assay (Enzyme-linked immunosorbent assay,ELISA) in 78 patients with SLE and 53 normal controls. The serum IL-34 levels were analyzed by Mann-Whitney U test). U test. Results: compared with the normal controls, the serum IL-34 level in the patients with SLE was significantly higher than that in the normal controls [(Median,128.9 pg/ml) vs (Median,52.4 pg/ml) / P0.001]. There was a positive correlation between the level of IL-34 and the disease activity of SLE, and the titer of double-stranded DNA antibody (anti-double stranded DNA antibody,anti-ds DNA) and C-reactive protein (C-reactive protein,CRP). There was a negative correlation with C3 level. Conclusion: serum IL-34 may be a serum marker of SLE because it is increased in SLE patients and correlated with disease activity.
【作者单位】： 重庆医科大学附属第一医院检验科;
【分类号】：R446.6;R593.241
，
本文编号：2247205
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