2013-2016年医院金黄色葡萄球菌分布特点及耐药性分析

发布时间：2018-09-18 15:37

【摘要】：目的通过分析耐甲氧西林金黄色葡萄球菌(MRSA)及对甲氧西林敏感金黄色葡萄球菌(MSSA)的分布及耐药性,为合理使用抗菌药物提供科学依据。方法选取2013-2016年医院临床检出分离并鉴定为金黄色葡萄球菌的细菌进行药物敏感性试验,根据其对甲氧西林敏感性分为MRSA和MSSA,分别对科室分布、标本来源及耐药性进行分析。结果共分离出782株MRSA和491株MSSA,MRSA的检出率占61.4%;MRSA和MSSA临床科室主要分布在神经外科分别占23.6%、31.0%,ICU分别占19.8%、13.2%,呼吸内科分别占13.3%、5.7%;MRSA和MSSA主要来源于痰标本,分别占65.7%和42.6%;MRSA对万古霉素、利奈唑胺、呋喃妥因、喹奴普汀/达福普汀的敏感率均95.00%,MSSA对苯唑西林、头孢唑林、亚胺培南、利奈唑胺100.00%敏感,对青霉素G的耐药率为94.1%。结论 MRSA对多种抗菌药物有较高的耐药性,MRSA耐药性明显大于MSSA,MSSA对大部分抗菌药物仍保持较好的敏感性,临床上应合理选用抗菌药物。
[Abstract]:Objective to analyze the distribution and drug resistance of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) in order to provide scientific basis for the rational use of antimicrobial agents. Methods the bacteria isolated and identified as Staphylococcus aureus from 2013 to 2016 were selected for drug sensitivity test. According to their sensitivity to methicillin, they were divided into MRSA and MSSA, to analyze the distribution of departments, the origin of specimens and the drug resistance respectively. Results A total of 782 MRSA strains and 491 MSSA,MRSA strains were isolated. The main clinical departments of MRSA and MSSA were located in neurosurgery department (23.61.0%) and in ICU (19.813.2%). The major sources of MRSA and MSSA in respiratory department were sputum (65.7%) and MSSA (42.6%) for vancomycin, respectively. The sensitivities of linazolamine, furantoin, quinuptin / dafopudine were 95.00%. MSSA was sensitive to oxacillin, cefazolin, imipenem, and linazolamide 100.00%, and the resistance rate to penicillin G was 94.1%. Conclusion MRSA has higher drug resistance to many kinds of antimicrobial agents. MRSA is more sensitive than MSSA,MSSA to most antimicrobial agents, so it is necessary to select antibiotics reasonably in clinic.
【作者单位】：宁波市第六医院重症医学科;宁波市医疗中心李惠利医院感染管理科;
【基金】：宁波市社会发展基金资助项目(2014C50047)
【分类号】：R446.5

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