血栓弹力图用于指导大量输血患者血浆输注的临床观察
发布时间:2018-11-14 13:34
【摘要】:目的:利用血栓弹力图(Thrombelastograph,TEG)监测大量输血(massive transfusion,MT)患者凝血功能动态变化,以此为依据指导大量输血患者新鲜冰冻血浆(fresh frozen plasma,FFP)的输注,探讨TEG在大量输血患者凝血功能监测中的作用及指导个体化精准血浆输注方案。方法:选择2015年5月~2016年12月术中进行大量输血的病人90例,ASA分级Ⅱ~Ⅳ级,年龄20~52岁,体重52~83kg。患者分为三组:大量血浆输注组(D组)30例,RBC:FFP=1:1;少量血浆输注组(S组)20例,RBC:FFP=2:1;TEG指导血浆输注组(T组),40例。(注:1URBC:100ml FFP=1:1)记录所有病人出血量、红细胞(Red blood cell,RBC)与FFP的输注量、晶胶体的输注量及输注血制品完成后即刻血栓弹力图的参数(R、K、α和MA)。利用SPSS22.0统计软件进行数据分析,p0.05认为差异有统计学意义。结果:三组患者的年龄、性别、身高、体重和ASA分级差异无统计学意义(p0.05)。三组患者在术中的出血量,RBC、晶体液和胶体液的输注量,差异无统计学意义,(p0.05)。术中新鲜冰冻血浆的输注量,D组明显大于T组与S组,差异有统计学意义(p0.05),T组与S组比,T组大于S组,差异有统计学意义(p0.05)。TEG监测的相关参数,与S组比,D组、T组的R值、K值明显减小,α值和MA值明显增大,差异有统计学意义(p0.05);T组与D组之间差异无统计学意义(p0.05)。结论:1、从血浆输注量比较:TEG指导血浆输注组明显小于大量血浆输注组,可避免不必要的血液制品浪费。2、从凝血功能方面比较,TEG指导血浆输注组与大量血浆输注组优于少量血浆输注组,能维持凝血功能状态相对稳定。3、TEG指导血浆输注组中的红细胞与血浆的输注比例集中于(1~2):1。4、TEG适合用于大量输血患者血浆输注的指导,并能提供个体化的血浆输注方案。
[Abstract]:Objective: to monitor the dynamic changes of coagulation function in patients with massive blood transfusion (massive transfusion,MT) by thromboelastography (Thrombelastograph,TEG), and to guide the infusion of fresh frozen plasma (fresh frozen plasma,FFP. To investigate the role of TEG in monitoring blood coagulation function in patients with massive blood transfusion and to guide individual accurate plasma infusion. Methods: from May 2015 to December 2016, 90 patients with ASA grade 鈪,
本文编号:2331309
[Abstract]:Objective: to monitor the dynamic changes of coagulation function in patients with massive blood transfusion (massive transfusion,MT) by thromboelastography (Thrombelastograph,TEG), and to guide the infusion of fresh frozen plasma (fresh frozen plasma,FFP. To investigate the role of TEG in monitoring blood coagulation function in patients with massive blood transfusion and to guide individual accurate plasma infusion. Methods: from May 2015 to December 2016, 90 patients with ASA grade 鈪,
本文编号:2331309
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