2013—2016年武汉市普仁医院老年患者下呼吸道感染病原菌的分布及耐药性分析

发布时间：2018-11-15 21:08

【摘要】：目的研究武汉市普仁医院老年患者下呼吸道感染病原菌的分布及耐药性,为临床合理使用抗菌药物提供经验依据。方法对武汉市普仁医院2013年1月—2016年6月老年患者下呼吸道感染病原菌的分布及耐药性进行回顾性分析。结果共分离出病原菌1 988株,其中革兰阴性菌1 728例,占86.9%;革兰阳性菌260例,占13.1%。肺炎克雷伯菌对常用抗菌药物的耐药率低于30%,而对氨苄西林的耐药率为100.0%;大肠埃希菌对青霉素类、头孢类、氟喹诺酮类、氨基糖苷类、复方新诺明的耐药率达30.0%~90.0%;阴沟肠杆菌对头孢西丁、氨苄西林、阿莫西林/克拉维酸、氨苄西林/舒巴坦、头孢唑啉的耐药率达68.0%~98.0%,对亚胺培南和美洛培南的耐药率均为0.0%。铜绿假单胞菌对常用抗菌药物的耐药率均低于20%;鲍曼不动杆菌对大部分抗菌药物的耐药率超过50%;嗜麦芽窄食单胞菌对所监测抗菌药物的耐药率低于15%。金黄色葡萄球菌中未发现万古霉素、替考拉宁和利奈唑胺的耐药菌株,青霉素G的耐药率达95.9%。肺炎链球菌对青霉素G、利奈唑胺和万古霉素的耐药率为100.0%。结论武汉市普仁医院老年患者下呼吸道感染病原菌谱分布广,仍以革兰阴性菌为主,其中多数耐药严重,临床应结合药敏试验,合理选用抗菌药物;同时要重视加强细菌耐药性的检测。
[Abstract]:Objective to study the distribution and drug resistance of pathogenic bacteria of lower respiratory tract infection in elderly patients in Puren Hospital, Wuhan, and to provide experience basis for rational use of antibiotics in clinic. Methods the distribution and drug resistance of pathogenic bacteria of lower respiratory tract infection in elderly patients from January 2013 to June 2016 in Puren Hospital of Wuhan City were analyzed retrospectively. Results A total of 1 988 strains of pathogenic bacteria were isolated, including 1 728 gram-negative bacteria (86. 9%) and 260 gram-positive bacteria (13. 1%). The resistance rate of Klebsiella pneumoniae to common antimicrobial agents was lower than 300.The resistance rate of Klebsiella pneumoniae to ampicillin was 100.0. The resistance rate of Escherichia coli to penicillin, cephalosporins, fluoroquinolones, aminoglycosides and compound sulfamide was 30.0% and 90.0%. The resistance rates of Enterobacter cloacae to cefoxitin, ampicillin, amoxicillin / clavulanic acid, ampicillin / sulbactam and cefazolin reached 68.0% and 98.0% respectively. The resistance rate of Pseudomonas aeruginosa to common antimicrobial agents was lower than 20%; Acinetobacter baumannii resistance rate to most antimicrobial agents was more than 50; and the resistance rate of Aeromonas maltophilia to antimicrobial agents monitored was lower than 15%. Vancomycin, teicoplanin and linazolamide resistant strains were not found in Staphylococcus aureus. The resistance rate of penicillin G was 95.9%. The resistance rate of Streptococcus pneumoniae to penicillin G, linazolamine and vancomycin was 100.0. Conclusion the pathogenic bacteria of lower respiratory tract infection in the elderly patients in Puren Hospital of Wuhan City are widely distributed, and Gram-negative bacteria are still the main pathogens. Most of them have serious drug resistance. At the same time, we should pay attention to strengthen the detection of bacterial resistance.
【作者单位】：武汉市普仁医院检验科;
【分类号】：R446.5;R56

【相似文献】