血清胃蛋白酶原、胃泌素17和幽门螺杆菌抗体检测在胃癌筛查中的应用

发布时间：2018-11-22 10:52

【摘要】：目的:探讨血清中胃蛋白酶原(PG)、胃泌素17(G-17)和幽门螺杆菌抗体(anti-HP)检测应用于胃癌筛查的可行性,阐明其临床价值。方法:选择早期胃癌患者208例作为观察组,同期体检正常者208人作为空白对照组。利用酶联免疫吸附试验和乳胶增强免疫比浊法检测2组受试者血清中PGⅠ、PGⅡ和G-17水平;采用13 C尿素呼吸试验检测2组受试者anti-HP阳性率,并对anti-HP阳性(anti-HP阳性组)和anti-HP阴性(anti-HP阴性组)受试者血清PGⅠ、PGⅡ水平和PGⅠ/PGⅡ比值进行比较分析。结果:与空白对照组比较,观察组患者血清PGⅠ/PGⅡ比值和PGⅠ水平明显降低(P0.01),而PGⅡ、G-17水平和anti-HP阳性率明显升高(P0.01);与anti-HP阴性组比较,anti-HP阳性组受试者血清PGⅠ/PGⅡ比值和PGⅠ水平明显降低(P0.01),而PGⅡ和G-17水平明显升高(P0.01)。结论:anti-HP阳性率结合PGⅠ/PGⅡ比值检测对于胃癌筛查具有重要的临床意义,提示上皮内瘤病变组织中G-17和PGⅡ水平可以作为胃癌前病变的观察指标。
[Abstract]:Objective: to investigate the feasibility of detection of pepsinogen (PG), gastrin 17 (G-17) and Helicobacter pylori antibody (anti-HP) in serum for gastric cancer screening and to elucidate its clinical value. Methods: 208 cases of early gastric cancer were selected as observation group and 208 cases of normal physical examination as blank control group. The levels of PG 鈪，

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