Presepsin在评估血必净注射液抗炎疗效中的应用

发布时间：2018-11-25 10:45

【摘要】：目的探讨可溶性白细胞分化抗原14亚型(sCD14-ST,Presepsin)在评估血必净注射液抗炎疗效方面的价值。方法收集2014年9月至2016年5月入住于广州中医药大学第一附属医院的60例脓毒症患者,随机分为治疗组和对照组,每组均30例,两组均按照"2012年严重脓毒症与脓毒性休克治疗国际指南"治疗。治疗组在常规集束化治疗基础上加用血必净注射液,连用5 d。对照组仅使用集束化治疗。检测各组治疗前及治疗后第1、3、5天的血清Presepsin、降钙素原、C反应蛋白含有量,并记录序贯器官衰竭评分。结果治疗后治疗组第1、3、5天的Presepsin、降钙素原、C反应蛋白值及序贯器官衰竭评分均低于对照组,差异具有统计学意义(P0.05)。治疗第1天Presepsin、序贯器官衰竭评分随治疗的进展开始下降,而降钙素原、C反应蛋白在治疗第3天达最高后逐渐下降。相关分析结果显示:治疗过程中,两组的Presepsin值与序贯器官衰竭评分呈线性相关(P0.01)。结论在脓毒症集束期使用血必净治疗,可减轻机体炎性反应,在一定程度上降低患者死亡率,改善疾病预后。Presepsin可以良好的评估和预测脓毒症的严重程度及预后,可以作为评估血必净抗炎疗效的有效指标。
[Abstract]:Objective to investigate the value of soluble leukocyte differentiation antigen 14 (sCD14-ST,Presepsin) in evaluating the anti-inflammatory effect of Xuebijing injection. Methods 60 patients with sepsis admitted to the first affiliated Hospital of Guangzhou University of traditional Chinese Medicine from September 2014 to May 2016 were randomly divided into treatment group and control group with 30 cases in each group. Both groups were treated according to the 2012 International guidelines for the treatment of severe sepsis and septic shock. The treatment group was treated with Xuebijing injection on the basis of conventional cluster therapy for 5 days. The control group was treated only with cluster therapy. Serum Presepsin, procalcitonin and C-reactive protein were measured before treatment and 5 days after treatment, and sequential organ failure scores were recorded. Results the Presepsin, procalcitonin, C-reactive protein and sequential organ failure scores in the treatment group were significantly lower than those in the control group on the 5th day after treatment (P0.05). On the first day of treatment, the Presepsin, Sequential Organ failure score began to decrease with the progress of treatment, while procalcitonin and C-reactive protein decreased gradually after reaching the highest level on the 3rd day of treatment. The results of correlation analysis showed that there was a linear correlation between the Presepsin value and the score of sequential organ failure (P0.01). Conclusion the treatment of Xuebijing in the cluster stage of sepsis can reduce the inflammatory reaction, reduce the mortality and improve the prognosis of the patients. Presepsin can be used to evaluate and predict the severity and prognosis of sepsis. It can be used as an effective index to evaluate the anti-inflammatory effect of Xuebijing.
【作者单位】：广州中医药大学第一附属医院重症医学科;
【分类号】：R459.7

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