新生儿脐部定植菌群特征分析

发布时间：2019-03-08 08:32

【摘要】：目的研究不同时期新生儿脐部细菌定植的分布特点,探讨脐部细菌定植与侵入性感染发生的可能联系。方法采用横断面整群抽样调查研究方法,对143例患儿的脐部残端拭子和血培养结果及临床资料进行回顾性分析。结果 143例患儿的脐部残端拭子培养有83.9%可见细菌生长,脐部细菌的定植率随着出生后时间的延长逐渐增高,出生后24 h内的定植率与24 h后的定植率有明显差异(P0.05)。两组常见的定植菌为凝固酶阴性葡萄球菌、大肠埃希菌和金黄色葡萄球菌,早期新生儿组(≤7 d)更易发生肠球菌、肺炎克雷伯菌、草绿色链球菌和无乳链球菌的定植。76例患儿同时进行了脐部拭子和血培养,发生血行侵入性感染的病例均来自早期新生儿组。结论新生儿脐部细菌定植大多在出生后24 h内完成。早期新生儿和晚期新生儿脐部皮肤优势定植细菌差异不大,但早期新生儿部分次优势菌定植可能导致侵入致病。早期新生儿脐部细菌定植发生血行侵入性感染机会大于晚期新生儿,无乳链球菌等特殊菌群血行感染率较高。
[Abstract]:Objective to study the distribution of neonatal umbilical cord bacterial colonization in different periods and to explore the possible relationship between umbilical cord bacterial colonization and invasive infection. Methods A total of 143 cases of umbilical cord swabs, blood culture and clinical data were retrospectively analyzed by cross-sectional cluster sampling. Results the bacterial growth was observed in 83.9% of the 143 cases of umbilical stump swab culture, and the colonization rate of the umbilical cord bacteria gradually increased with the prolongation of postnatal time. The colonization rate within 24 hours after birth was significantly different from that after 24 hours (P0.05). The common colonization bacteria in the two groups were coagulase-negative staphylococcus, Escherichia coli and Staphylococcus aureus. The early neonatal group (鈮，

本文编号：2436623