自体外周血造血干细胞移植的造血重建分析

发布时间：2019-03-29 16:09

【摘要】：目的:探讨自体外周血造血干细胞移植(auto-PBHSCT)过程中造血重建的影响因素。方法:回顾性分析接受auto-PBHSCT的177例病人的造血重建成功率、造血重建时间和移植后28 d造血重建状态,探索造血重建的影响因素。结果:粒系中位植入时间为12(8-21)d,植入率98.9%,均在28 d内植入;血小板中位植入时间为17(7-420)d,植入率95.5%,移植后28 d血小板累积植入率80.8%。单因素分析结果显示,回输CD34~+细胞数量和rh TPO的使用是粒细胞植入时间的影响因素;而疾病种类、预处理方案、回输CD34~+细胞数量是血小板植入时间的影响因素。多因素分析结果表明,回输CD34~+细胞数量是粒细胞植入时间的独立影响因素,而疾病种类、回输CD34~+细胞数量是血小板植入时间的独立影响因素。疾病种类和回输CD34~+细胞数量是移植后28 d造血重建状态的独立影响因素。结论:对于auto-PBHSCT而言,疾病种类、预处理方案、回输CD34~+细胞数量、rh TPO的使用是造血重建的影响因素。
[Abstract]:Objective: to investigate the influential factors of hematopoietic reconstitution in autologous peripheral blood stem cell transplantation (auto-PBHSCT). Methods: the successful rate of hematopoiesis reconstruction, the time of hematopoiesis reconstruction and the state of hematopoiesis reconstitution 28 days after transplantation were retrospectively analyzed in 177 patients receiving auto-PBHSCT, and the influencing factors of hematopoietic reconstitution were explored. Results: the median implantation time was 12 (8? 21) days, the implantation rate was 98.9%, all of them were implanted within 28 days. The median time of platelet implantation was 17 (7 渭 420) days, the implantation rate was 95.5%, and the cumulative platelet implantation rate was 80.8% on the 28th day after transplantation. The results of univariate analysis showed that the number of CD34~ cells and the use of rh TPO were the influencing factors of the time of granulocyte implantation, and the type of disease, the pretreatment scheme and the number of CD34~ cells were the influencing factors of the time of platelet implantation. The results of multivariate analysis showed that the number of CD34~ cells was the independent factor influencing the time of granulocyte implantation, and the type of disease and the number of CD34~ cells were the independent factors influencing the time of platelet implantation. The type of disease and the number of CD34~ cells were independent influencing factors of hematopoiesis reconstitution 28 days after transplantation. Conclusion: as far as auto-PBHSCT is concerned, the type of disease, the pre-treatment scheme and the use of, rh TPO in the number of CD34~ cells re-infused are the influencing factors of hematopoiesis reconstruction.
【作者单位】：中国人民解放军总医院血液科;
【分类号】：R457.7

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