脐带间充质干细胞治疗儿童造血干细胞移植后难治性急性移植物抗宿主病及出血性膀胱炎的疗效观察

发布时间：2019-04-10 16:03

【摘要】：目的谈讨脐带间充质干细胞(umbilical cord-mesenchymal stem cells,UCMSCs)治疗异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,allo-HSCT)后儿童急性移植物抗宿主病(acute graft versus host disease,a GVHD)及出血性膀胱炎(hemorrhagic cystitis,HC)的疗效及安全性。方法异基因造血干细胞移植后发生难治性a GVHD及HC儿童共15例,其中a GVHD13例(Ⅰ度a GVHD 2例,Ⅲ度a GVHD 8例,Ⅳ度a GVHD 5例)、HC 5例(Ⅲ度4例,Ⅳ度1例)。在常规治疗效果不佳的基础上,联合静脉输注UCMSCs。UCMSCs的平均使用剂量为3.6(1.25~6.0)×106,平均使用次数为5次(2~21次)。然后观察a GVHD及HC的恢复、再发情况及输注后不良反应。结果allo-HSCT后发生a GVHD的全部13例患儿在对一线免疫抑制剂及CD25单抗治疗无效,联合UCMSCs治疗后,8例获得完全缓解,5例获得部分缓解;5例HC患儿经水化、碱化治疗后效果欠佳,联合静脉输注UCMSCs后症状缓解。本研究未观察到UCMSCs输注相关的不良反应。结论联合UCMSCs治疗异基因造血干细胞移植后儿童a GVHD及HC安全有效。
[Abstract]:Objective to discuss the effect of umbilical cord mesenchymal stem cells (umbilical cord-mesenchymal stem cells,UCMSCs) on acute graft versus host disease (acute graft versus host disease,) in children after allogeneic hematopoietic stem cell transplantation (allogeneic hematopoietic stem cell transplantation,allo-HSCT). Efficacy and safety of a GVHD) and hemorrhagic cystitis (hemorrhagic cystitis,HC). Methods Fifteen children with refractory a-GVHD and HC after allogeneic hematopoietic stem cell transplantation (HSCT), including a-GVHD13 in 2 cases, a-GVHD in 8 cases, and), HC in 5 cases in grade 鈪，

本文编号：2455935