血小板参数与输注疗效及预后判断的相关性分析

发布时间：2019-08-03 07:22

【摘要】：目的探讨血小板相关参数与单采血小板输注疗效之间的相关性,为临床诊断提供指导意义。方法通过回顾性的分析本院2014-2016年输注单采血小板的患者50例,根据首次输注1个治疗量血小板后d 5复查血常规结果,血小板计数升至正常范围为增长组(27人),血小板计数未达正常范围为降低组(23人)。分别比较分析2组输注前和输注后24 h内血小板相关系数包括血小板计数(Plt),血小板分布宽度(PDW),平均血小板体积(MPV),大血小板比率(P-LCR)的改变,同时计算24 h血小板纠正计数指数(CCI)。结果 24 h CCI4.5增长组有21例占77.78%,降低组有11例占47.83%;输注前血小板相关参数两组间比较没有显著差异(P0.05),输注后,增长组Plt,PDW,MPV和P-LCR明显高于降低组(P0.01);其中输血前后数据相比较增长组MPV,P-LCR全部增高,降低组MPV,P-LCR则全部降低。结论血小板参数检测特别是MPV和P-LCR的改变趋势对于血小板输注的疗效观察与预后判断具有重要的临床意义。
[Abstract]:Objective to investigate the correlation between platelet related parameters and the curative effect of platelet transfusion, and to provide guiding significance for clinical diagnosis. Methods from 2014 to 2016, 50 patients with single platelet transfusion in our hospital were analyzed retrospectively. according to the results of routine examination on the day 5 after the first infusion of 1 therapeutic volume of platelet, the platelet count increased to the normal range (27 patients) and the platelet count did not reach the normal range (23 patients). The results showed that the platelet count increased to the normal range (27 patients) and the platelet count did not reach the normal range (23 patients). The platelet correlation coefficient, including platelet count (Plt), platelet distribution width, (PDW), mean platelet volume (MPV), large platelet ratio (P-LCR), was compared between the two groups before and 24 hours after infusion, and the platelet correction index (CCI). Was calculated at the same time. Results there were 21 cases (77.78%) in 24 h CCI4.5 growth group and 11 cases (47.83%) in decreased group. There was no significant difference in platelet related parameters between the two groups before infusion (P 0.05). After infusion, Plt,PDW,MPV and P-LCR in the growth group were significantly higher than those in the decrease group (P 0.01), and the MPV,P-LCR in the increase group was all higher than that in the decrease group before and after transfusion, while the MPV,P-LCR in the decreased group was all decreased. Conclusion the detection of platelet parameters, especially the changing trend of MPV and P-LCR, is of great clinical significance for the observation of curative effect and prognosis of platelet transfusion.
【作者单位】：复旦大学附属华山医院输血科;
【基金】：国家自然科学基金面上项目(81470351) 上海市公共卫生重点学科建设项目(15GWZK0501)
【分类号】：R457.1

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