海南地区类鼻疽伯克霍尔德菌的药物敏感性分析

发布时间：2019-08-02 19:58

【摘要】：目的探讨海南地区类鼻疽伯克霍尔德菌(BP)对常用抗生素的敏感性。方法以2008年1月—2013年3月在海南地区患者中分离的101株非重复类鼻疽伯克霍尔德菌作为研究对象,采用E-test法对目前国际上常用于治疗类鼻疽的抗生素进行药物敏感试验分析。结果本实验收集的101株类鼻疽菌中主要是以败血症为主,共有60人(59.4%),其次是肺部感染22人(21.8%),伤口及皮肤软组织感染有17人(16.8%),尿路感染2人(2.0%),受试者总死亡率为17.8%(18/101),其中72.2%(13/18)的死亡患者见于败血症患者。体外药敏试验结果显示,本次分离的所有类鼻疽对美罗培南、亚胺培南、左氧氟沙星、头孢他啶和阿莫西林/克拉维酸均显示良好的敏感性,敏感率分别为100%、100%、94.4%、92.1%和90.1%。对四环素和复方磺胺甲VA唑的敏感率分别为85.1%和84.2%。结论本研究和其他地区的报道都证实了类鼻疽伯克霍尔德菌对目前国际上常用于治疗该疾病的抗生素呈现良好的敏感性,其中以亚胺培南和美罗培南的敏感性最好,可作为治疗的首选。
[Abstract]:Objective to investigate the sensitivity of Burkholderia gangrenosum (BP) to common antibiotics in Hainan. Methods from January 2008 to March 2013, 101 strains of Berkholderia gangrenoides isolated from patients in Hainan area were selected as the object of study. E-test method was used to analyze the drug sensitivity test of antibiotics commonly used in the treatment of gangrene in the world. Results among the 101 strains of gangrene, 60 cases (59.4%) were septicemia, 22 cases (21.8%) were pulmonary infection, 17 cases (16.8%) were wound, skin and soft tissue infection, 2 cases (2.0%) were urinary tract infection, and the total mortality rate was 17.8% (18 鈮，

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