黑豆洗方外用治疗手部湿疹的临床疗效观察及作用机理探讨

  本文关键词：黑豆洗方外用治疗手部湿疹的临床疗效观察及作用机理探讨，由笔耕文化传播整理发布。

黑豆洗方外用治疗手部湿疹的临床疗效观察及作用机理探讨

黑豆洗方外用治疗手部湿疹的临床疗效观察及作用机理探讨

手部湿疹是皮肤科临床的常见病、多发病，中药治疗该病疗效显著。本课题应用中医理论及现代技术从临床和实验两方面观察了导师用于临床多年的经验方——黑豆洗方外用治疗手部湿疹的临床疗效并对其作用机理进行了初步探讨。临床观察中，黑豆洗方外用治疗手部湿疹59例，，治愈率32.2％、总有效率67.8％，与去炎松尿素软膏组疗效相当，且在对各种临床症状及自觉症状的改善方面及远期疗效明显优于后者。实验部分通过抗炎实验、抗过敏性接触性皮炎实验、止痒实验和对兔皮肤刺激实验说明该药外用具有抗Ⅳ型变态反应、止痒的作用，且对皮肤无刺激性。本研究认为黑豆洗方外用治疗手部湿疹疗效肯定，复发率低，其良好的润肤、止痒、抗Ⅳ型变态反应作用为本病的治疗提供了部分临床及理论依据。

【Abstract】 Hand eczema(HE) is a common dermatologic disease.Traditional Chinese Medicine (TCM) has broad prospects in treating it.Based on my tutor ,professor Du Xixian’s abundant clinical experiences and the reference of ancient and modern bibliography,the dissertation is aimed to select an effective external lotion -Heidou lotion in treating hand eczema and to study the treating mechanism of it.The project is made up of two parts:the clinical study and the experimental study. In clinical study, 93 patients of HE were divided into two groups at random: 59 cases were treated with Heidou totion while the other 34 cases were treated with Triamcinolone Acetonide Acetate Urea Cream.Result: the HD lotion group’s clinical cure rate is 32.2% and the total effective rate is 67.8%,while the control group’s clinical cure rate is 20.59% and the total effective rate is 52.94%.These two have no notable difference through statistical analysis. And the curative effect of the HD lotion group after 3 months is better than that of the control group.In experimental study ,through experiments on animal models results show that Heidou lotion has little anti-acurate inflammation effect and notable anti-IV hypersensitivity effect with little irritation to the skin.Through all these studies we can see that with good clinical effect and definite anti-IV hypersensitivity effect,HD lotion is a economical external TCM compound in treating HE.But we still have much work to do .For example, we must further the experimental studies in order to know the exact treating mechnism of HD lotion.

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  本文关键词：黑豆洗方外用治疗手部湿疹的临床疗效观察及作用机理探讨，由笔耕文化传播整理发布。