Responsive Multilayer and Hydrogel Based Drug for Resisting

发布时间：2021-04-13 21:17

　　The bacterial colonization and adhesion on biomedical implants and subsequent biofilm formation often lead to serious bacterial infections.The sudden rise in antibiotic-resistant bacterial infections is the main reason for life-threatening infection diseases.Currently,intravenous antibiotic injection is the most practicing way to deal with implant-associated infections.However,the occurrence of antibiotic-resistant bacteria has become more dangerous by misuse and taking a huge amount of antibiot... 

【文章来源】：浙江理工大学浙江省

【文章页数】：68 页

【学位级别】：硕士

【文章目录】：
Abstract
Chapter 1 Introduction
    l.l Background of Antibacterial Biomaterials
    1.2 Controlled Drug Delivery System
    1.3 Antimicrobials for Antibacterial Biomaterials
    1.4 Classification of Antibacterial Biomaterial
        1.4.1 Inorganic Antibacterial Materials
        1.4.2 Synthesized Organic Antibacterial Materials
        1.4.3 Natural antibacterial Materials
    1.5 Stimuli-Responsive Delivery Systems
        1.5.1 Drugs Delivery Systems （DDS）
        1.5.2 Redox Responsive
        1.5.3 Thermal Responsive
        1.5.4 EnzymeResponsive
        1.5.5 pH Responsive
    1.6 Multilayer System for Drug Delivery
        1.6.1 Synthesized Polymer basedMultilayer System
        1.6.2 Natural Polymer based Multilayer System
        1.6.3 Heavy Metal-Based Multilayer System
    1.7 Other Advanced Methodologiesfor Responsive Drug Delivery System
    1.8 Purpose and Innovativeness
Chapter 2 Fabrication of a pH and hyaluronidase dual-responsive multilayer-based drugdelivery system
    2.1 Preface
    2.2 Experimental
        2.2.1 Materials
        2.2.2 Construction of Layer-by-layer Multilayer
        2.2.3 Adsorption and cross-linking of HA onto the multilayer surface
        2.2.4 Loading and release kinetics of GS
        2.2.5 Surface Characterization
        2.2.6 Antibacterial test
    2.3 Results and Discussions
        2.3.1 Construction and characterization of multilayers surface
        2.3.2 Loading and Release kinetics of GS into and from multilayer
        2.3.3 Drug release kinetics of multilayers
        2.3.4 Antibacterial behavior of multilayers
    2.4 Conclusion
Chapter3 Fabrication of ahydrogel-based drug delivery system with photothermal effect
    3.1 Preface
    3.2 Experimental
        3.2.1 Materials
        3.2.2 Preparation of silk fibroin
        3.2.3 Polymer synthesizes
        3.2.4 Preparation of HPAE-Py/silk fibroin hydrogels
        3.2.5 Characterization of HPAE-Py
        3.2.6 Determination of gelation efficiency
        3.2.7 Determination of swelling
        3.2.8 Drug release behavior
        3.2.9 Determine of Antibacterial Activity
        3.2.10 Statistical analysis
    3.3 Result and Discussions
        3.3.1 Analysis of the Chemical Structure
        3.3.2 Gelation efficiency
        3.3.3 Swelling behavior
        3.3.4 Assessment of GS Drug release from hydrogel
        3.3.5 Assessment of photothermal effect
        3.3.6 Antibacterial Activity
Chapter 4 Conclusion
Chapter 5 Deficiency and Prospect
References
PUBLICATIONS
Acknowledgments



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