闽南地区汉族人群常染色体15个STR基因座遗传多态性的研究

发布时间：2018-07-17 19:22

【摘要】：背景与目的分子生物学的进步使得人类在认识自己的起源方面取得了突破性的进展。随着分子生物学技术的发展及不断完善，我国学者利用DNA多态性对我国各民族的起源、迁徙、分化、融合等进行了一系列的探索。闽南地区主要包含厦门、漳州、泉州三个地区，由于历史上战乱等原因而不断迁徙，在广东的潮汕地区、台湾省、海南省、浙江省等地也有生活习俗、语言相近的汉族人群，在海外分布的闽南籍侨民更是超过1000万，而总人口在5000万以上。研究闽南地区的人群的基因多态性，发掘其多态信息量具有重大的历史学、人类学、法医学意义。材料与方法利用基因扫描技术对中国闽南地区122例汉族人群的15个STR基因座遗传多态性进行研究，结合历史学、人类学等相关文献资料，探讨闽南地区汉族人群的起源及其与美国黑人、美国白人，广东潮汕、中国台湾、河南、天津、山西、浙江汉族亚群等不同种族、民族、人群之间的差异度及亲缘关系。结果本次调查研究结果显示，中国闽南地区汉族常染色体15个STR基因座(CSF1PO、D7S820、D8S1179、D21S11、D2S1338、D3S1358、D13S317、D16S539、TH01、D18S51、D19S433、TPOX、vWA、D5S818、FGA)共检出130个等位基因，其频率分布在0.0041～0.5123之间；检出371种基因型，其频率分布在0.008～0.352之间。其中D8S1179基因座检出10个等位基因、31种基因型，频率分布在0.0041～0.1967和0.008～0.090之间。D21S11基因
[Abstract]:Background and objective: the progress of molecular biology has made a breakthrough in understanding the origin of human beings. With the development and improvement of molecular biology technology, Chinese scholars have used DNA polymorphism to explore the origin, migration, differentiation and fusion of different nationalities in China. The southern Fujian region mainly includes three areas, Xiamen, Zhangzhou, and Quanzhou, which have been migrating because of historical wars and other reasons. There are also people of Han nationality with similar languages in the Chaoshan, Taiwan, Hainan, and Zhejiang provinces of Guangdong. More than 10 million Minnan nationals live overseas, with a total population of more than 50 million. It is of great significance in history, anthropology and forensic medicine to study the genetic polymorphism of the population in the south of Fujian and to explore the amount of polymorphic information. Materials and methods genetic polymorphisms of 15 STR loci in 122 Han population in South Fujian, China, were studied by gene scanning technique. The origin of Han nationality in South Fujian and its relationship with black Americans, white Americans, Chaoshan, Taiwan, Henan, Tianjin, Shanxi, Zhejiang, etc. The difference and relationship between people. Results the results of this investigation showed that 130 alleles were detected in 15 STR loci of Han nationality in South Fujian, China (CSF1POD7S820D8S1179 (D21S11S11D2S1338) D13S317F13S317F16S539 / TH01D18S51D19S433TPOXVWAD5S818FGA). Its frequency was between 0.0041 and 0.5123, and 371 genotypes were detected, and its frequency was between 0.008 and 0.352. Among them, 31 genotypes of 10 alleles were detected in D8S1179 locus, and the frequency distribution was between 0.0041 and 0.008 / 0. 090. D21S11 gene.
【学位授予单位】：汕头大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：D919

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