尿中MDMA和MDA的酰基衍生化-氮磷检测气相色谱分析法
发布时间：2018-11-09 18:52
【摘要】：研究了致幻性安非他明类药物3,4-亚甲二氧基甲基安非他明(MDMA)和3,4-亚甲二氧基安非他明(MDA)的乙酰化、三氟乙酰化、五氟丙酰化、七氟丁酰化、二氯乙酰化、一氯二氟乙酰化、五氟苯甲酰化、五氟苯磺酰化和二硝基苯甲酰化的衍生化反应条件,发现除了乙酰化之外所研究的各种衍生化反应均可用5μL酸酐或酰氯在环己烷中于20℃10 m in内完成。乙酰化可用20μL乙酸酐在60℃30 m in内完成。在此基础上建立了尿中MDMA和MDA的各种衍生化的氮磷检测气相色谱(GC/NPD)分析方法。方法操作简便快速,绝大多数方法的检出限低于10μg/L,其中二氯乙酰化、一氯二氟乙酰化、五氟苯甲酰化、五氟苯磺酰
[Abstract]:The acetylation, trifluoroacetylation, pentafluoropropionylation, heptafluorobutyloylation and dichloroacetylation of the hallucinogenic amphetamines 3- (4-methylene) methamphetamine (MDMA) and 3- (4-methylenedioxyamphetamine) (MDA) were studied, Conditions for the derivatization of monochlorodifluoroacetylation, pentafluorobenzoylation, pentafluorobenzenesulfonylation and dinitrobenzoylation, It was found that all the derivation reactions except acetylation could be completed in cyclohexane at 20 鈩，
本文编号：2321274
[Abstract]:The acetylation, trifluoroacetylation, pentafluoropropionylation, heptafluorobutyloylation and dichloroacetylation of the hallucinogenic amphetamines 3- (4-methylene) methamphetamine (MDMA) and 3- (4-methylenedioxyamphetamine) (MDA) were studied, Conditions for the derivatization of monochlorodifluoroacetylation, pentafluorobenzoylation, pentafluorobenzenesulfonylation and dinitrobenzoylation, It was found that all the derivation reactions except acetylation could be completed in cyclohexane at 20 鈩，
本文编号：2321274
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