重庆地区暴力罪犯的DRD4基因外显子Ⅲ VNTR多态性、心理和生活环境的关联性分析
发布时间：2019-04-12 13:13
【摘要】：暴力犯罪是指为获取某种利益或满足某种欲求而对他人人身采取的暴力侵害行为。尽管暴力犯罪发案率较小,但其社会危害性远大于其它犯罪,对该类犯罪的打击和防范也是公安工作的重点。对于罪犯形成的原因一直是该领域重要课题。有研究表明DRD4是哺乳动物大脑内的重要多巴胺受体之一,对多种生理功能均有调控作用,其涉及的重大疾病主要包括精神分裂症、帕金森病等。近年来对多巴胺(DA)与成瘾物质、精神应激关系的认识更极大地促发了人们对DA与暴力行为相关性的研究。而且有研究证明DRD4基因VNTR的多态性与情感障碍有关。而且研究证明该基因的长VNTR (L)型与DRD4受体活性有关。 为研究重庆地区暴力罪犯该基因型的分布,与心理及环境间的关联,进一步揭示犯罪行为学的遗传学基础。本项目以DRD4基因VNTR的多态性为指标,比较对照组622人(正常无血缘关系人群)与实验组621人(具有暴力犯罪倾向人群)在DRD4基因外显子ⅢVNTR (48bp)的基因型和等位基因频率分布。应用艾森克心理问卷评测了神经和精神因素,应用粗糙集数据挖掘的方法分析了家庭环境、心理和DRD4基因多态性与暴力犯罪的关联。结果显示： 1、在本研究中DRD4以等位基因4最多,2次之,检出最大等位基因为7,未有8以上重复序列检出；对DRD4检测到的等位基因按照短(S)、长(L)重复序列进行分类统计分析,结果DRD4重复次数在两个年龄段的罪犯与正常人群均无显著差异,但长等位基因(L)在犯罪人群中的分布频率较正常人群的比例大。 2、背景调查显示文盲或小学文化程度、家庭经济状况不佳的未成年人犯盗窃、抢劫等财产性犯罪几率高,犯罪人员均没有接受良好的教育,文化程度低下。 3、心理调查表明神经、精神因素与各种犯罪关系密切,其中神经质维度极高、精神质维度极高的犯抢劫罪、杀人罪、敲诈勒索罪、强奸罪或故意伤害罪等重罪可能性大。 4、DRD4基因exonⅢVNTR的多态性基因型为4/4的,生活在中等以下条件、中学以下学历,及神经质和精神质偏高的个体可能更容易出现暴力倾向；DRD4基因exonⅢ基因型4/4与杀人类犯罪及18-30岁抢劫类犯罪的关联性偏高。
[Abstract]:Violent crime refers to the act of violence against others in order to obtain some benefit or satisfy some desire. Although the incidence rate of violent crime is relatively small, its social harmfulness is far greater than other crimes, and the attack and prevention of this kind of crime is also the focus of public security work. The reason for the formation of criminals has always been an important topic in this field. Some studies have shown that DRD4 is one of the important dopamine receptors in mammalian brain, which regulates many physiological functions. The major diseases involved include schizophrenia, Parkinson's disease and so on. In recent years, the understanding of the relationship between dopamine (DA) and addictive substance, mental stress has greatly promoted the study of the relationship between DA and violent behavior. Moreover, it has been proved that the polymorphism of DRD4 gene VNTR is associated with affective disorder. Moreover, it has been proved that the long VNTR (L) type of the gene is related to the activity of DRD4 receptor. In order to study the distribution of the genotype of violent criminals in Chongqing and the relationship with psychology and environment, the genetic basis of criminal behavior was further revealed. In this study, the polymorphism of DRD4 gene VNTR was used as an index. The distribution of genotype and allele frequencies in exon 鈪，
本文编号：2457047
[Abstract]:Violent crime refers to the act of violence against others in order to obtain some benefit or satisfy some desire. Although the incidence rate of violent crime is relatively small, its social harmfulness is far greater than other crimes, and the attack and prevention of this kind of crime is also the focus of public security work. The reason for the formation of criminals has always been an important topic in this field. Some studies have shown that DRD4 is one of the important dopamine receptors in mammalian brain, which regulates many physiological functions. The major diseases involved include schizophrenia, Parkinson's disease and so on. In recent years, the understanding of the relationship between dopamine (DA) and addictive substance, mental stress has greatly promoted the study of the relationship between DA and violent behavior. Moreover, it has been proved that the polymorphism of DRD4 gene VNTR is associated with affective disorder. Moreover, it has been proved that the long VNTR (L) type of the gene is related to the activity of DRD4 receptor. In order to study the distribution of the genotype of violent criminals in Chongqing and the relationship with psychology and environment, the genetic basis of criminal behavior was further revealed. In this study, the polymorphism of DRD4 gene VNTR was used as an index. The distribution of genotype and allele frequencies in exon 鈪，
本文编号：2457047
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