可用于血清游离铜快速检测的特异性识别元件
发布时间：2018-08-30 12:51
【摘要】：铜离子广泛存在于环境和食品中,机体中游离铜离子含量增加可导致神经系统功能紊乱和肝、肾损害等。目前铜离子的检测方法主要有:原子吸收光谱法(AAS)、电感耦合等离子体原子发射光谱法(ICP-AES)和电感耦合等离子体质谱法(ICPMS),这些方法虽然检测结果准确、灵敏度高,但仪器昂贵、样品处理复杂且不能区分铜离子的存在形态。因此,探索基于铜离子特异性识别元件构建的荧光或电化学检测方法在游离铜快速特异性响应中的应用受到了广泛青睐,其对应的铜离子特异性识别元件如有机小分子、纳米材料、生物分子等亦得到了不断地丰富和发展。有机小分子设计灵活,纳米材料响应灵敏,生物分子特异性强、生物相容性好,此三者作为特异性识别元件在血清游离铜的检测中具有广阔的应用前景。
[Abstract]:Copper ions widely exist in the environment and food. The increase of free copper ions in the body can lead to nervous system dysfunction and liver and kidney damage. At present, the main methods for the determination of copper ions are: (AAS), inductively coupled plasma atomic emission spectrometry (ICP-AES) and inductively coupled plasma-mass spectrometry (ICPMS),). These methods are accurate and sensitive, but the instruments are expensive. The sample treatment is complex and can not distinguish the existing forms of copper ions. Therefore, the application of fluorescent or electrochemical detection methods based on copper ion specific recognition elements to the rapid specific response of free copper has been widely used, and the corresponding copper ion specific recognition elements such as organic small molecules have been widely used. Nanomaterials and biomolecules have also been enriched and developed. The design of organic small molecules is flexible, the nanomaterials are sensitive, the biomolecules are specific, and the biocompatibility is good. As special recognition elements, these three elements have a broad application prospect in the detection of serum free copper.
【作者单位】： 首都医科大学公共卫生学院;
【基金】：北京市教育委员会科技发展计划重点项目(KZ201510025027) 首都医科大学优秀学术带头人及团队交流培养项目
【分类号】：X830
，
本文编号：2213120
[Abstract]:Copper ions widely exist in the environment and food. The increase of free copper ions in the body can lead to nervous system dysfunction and liver and kidney damage. At present, the main methods for the determination of copper ions are: (AAS), inductively coupled plasma atomic emission spectrometry (ICP-AES) and inductively coupled plasma-mass spectrometry (ICPMS),). These methods are accurate and sensitive, but the instruments are expensive. The sample treatment is complex and can not distinguish the existing forms of copper ions. Therefore, the application of fluorescent or electrochemical detection methods based on copper ion specific recognition elements to the rapid specific response of free copper has been widely used, and the corresponding copper ion specific recognition elements such as organic small molecules have been widely used. Nanomaterials and biomolecules have also been enriched and developed. The design of organic small molecules is flexible, the nanomaterials are sensitive, the biomolecules are specific, and the biocompatibility is good. As special recognition elements, these three elements have a broad application prospect in the detection of serum free copper.
【作者单位】： 首都医科大学公共卫生学院;
【基金】：北京市教育委员会科技发展计划重点项目(KZ201510025027) 首都医科大学优秀学术带头人及团队交流培养项目
【分类号】：X830
，
本文编号：2213120
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