磺胺类抗性基因的产生及演变研究进展
发布时间：2019-07-26 16:48
【摘要】：磺胺类抗生素是人工合成的高效广谱抗菌药,广泛用于畜牧养殖、水产养殖和人类疾病治疗中。但其长期排放和累积残留会诱导产生抗生素抗性基因(ARGs)。ARGs作为一种新型的环境污染物,在环境中的持久性残留、复制、传播和扩散比抗生素本身的危害更大。通过对磺胺类ARGs及耐药微生物产生和传播进行综述,提出"渐变→累积→突变"的ARGs演变模型。最后针对中国提出磺胺类ARGs未来的研究重点。
[Abstract]:Sulfonamides are synthetic and high-efficiency broad-spectrum antibiotics, which are widely used in animal husbandry, aquaculture and the treatment of human diseases. However, its long-term emission and cumulative residue will induce the production of antibiotic resistance gene (ARGs). As a new type of environmental pollutant, the persistent residue, replication, transmission and diffusion in the environment are more harmful than the antibiotic itself. Based on the review of the production and transmission of sulfonamides ARGs and drug-resistant microorganisms, a ARGs evolution model of "gradual cumulative mutation" was proposed. Finally, the future research focus of sulfonamides ARGs is put forward in China.
【作者单位】： 东华大学环境科学与工程学院;
【基金】：上海市科技攻关项目(No.033919457)
【分类号】：X592
，
本文编号：2519670
[Abstract]:Sulfonamides are synthetic and high-efficiency broad-spectrum antibiotics, which are widely used in animal husbandry, aquaculture and the treatment of human diseases. However, its long-term emission and cumulative residue will induce the production of antibiotic resistance gene (ARGs). As a new type of environmental pollutant, the persistent residue, replication, transmission and diffusion in the environment are more harmful than the antibiotic itself. Based on the review of the production and transmission of sulfonamides ARGs and drug-resistant microorganisms, a ARGs evolution model of "gradual cumulative mutation" was proposed. Finally, the future research focus of sulfonamides ARGs is put forward in China.
【作者单位】： 东华大学环境科学与工程学院;
【基金】：上海市科技攻关项目(No.033919457)
【分类号】：X592
，
本文编号：2519670
本文链接：https://www.wllwen.com/shengtaihuanjingbaohulunwen/2519670.html
