基于聚乙二醇共聚物环境敏感水凝胶的制备与研究

发布时间：2017-12-28 20:44

本文关键词：基于聚乙二醇共聚物环境敏感水凝胶的制备与研究　出处：《华东师范大学》2017年硕士论文　论文类型：学位论文

【摘要】：环境敏感性材料是当今研究的一个热点,本文合成并研究了一系列温度和pH敏感性聚合物水凝胶,具体工作如下:1.通过自由基共聚的方法,采用聚乙二醇(PEG)聚合度为9的低聚乙二醇甲醚丙烯酸酯(OEGA)和乙二醇甲醚丙烯酸酯(MEA),成功制备了一系列温度敏感性的P(MEA-co-OEGA)共聚物水凝胶,固体核磁共振氢谱(1H/MAS)确认了结构,变温紫外测试(UY-vis)和溶胀率(ESR)测试表明其具有温敏性,且低临界相转变温度(LCST)可控,用高场静态固体核磁共振和低场核磁共振的方法结合,探究了水凝胶内部的运动性,研究了水凝胶中水的不同状态及相对含量,初步得出该水凝胶温敏性的微观机制。2.在P(MEA-co-OEGA)共聚物水凝胶的基础上,引入甲基丙烯酸-N,N-二甲氨基乙酯(DMAEMA)单体与MEA和OEGA单体进行自由基共聚,得到了温度和pH双重敏感的P(MEA-co-OEGA-co-DMAEMA)水凝胶,可以作为二氧化碳响应器件、调光材料和药物控制释放载体等。3.用分子量300的聚乙二甲醚丙烯酸酯(O5EGMA)作为单体,在羧甲基纤维素(CMC)水溶液中原位聚合,得到温敏性的半互穿网络(semi-IPN)纤维素水凝胶,溶胀率测试表明CMC含量越多,溶胀率越大,去溶胀越快,加入共聚单体MEA可以调节其LCST至35℃,接近人体体温,有望在生物医药等领域得到应用。
[Abstract]:The environment sensitive material is a hotspot of research in this paper, the synthesis and study of a series of temperature and pH sensitive polymer hydrogel, the specific work is as follows: 1. through the method of free radical copolymerization, using polyethylene glycol (PEG) with low degree of polymerization of Acrylate Polyethylene Glycol 9 (OEGA) and ethylene glycol monomethyl ether acrylate (MEA). A series of temperature sensitivity of P was successfully prepared (MEA-co-OEGA) copolymer hydrogels, solid nuclear magnetic resonance spectroscopy (1H/MAS) confirmed the structure, ultraviolet (UY-vis) test and swelling ratio (ESR) test proves its temperature sensitivity, and low critical phase transition temperature (LCST) combined with high controllable. The static field NMR and low field NMR method, explores the movement of the hydrogel interior, various state and relative content of water in hydrogel, preliminary draw the microscopic mechanism of temperature sensitive hydrogels. 2. in P (MEA-co-OEGA) based on the introduction of the copolymer hydrogel, methacrylic acid -N, N- two dimethylamino ethyl (DMAEMA) monomer with MEA and OEGA monomers by free radical copolymerization, the temperature and pH sensitive hydrogel, P (MEA-co-OEGA-co-DMAEMA) can be used as two carbon materials and devices, light response drug delivery systems. 3. with a molecular weight of 300 poly two methyl ether acrylate (O5EGMA) as the monomer, the carboxymethyl cellulose (CMC) in situ polymerization in aqueous solution, obtained thermosensitive semi interpenetrating network (semi-IPN) cellulose hydrogel, swelling rate test showed that the content of CMC increasing, the swelling ratio is large, the swelling to more quickly. Adding comonomer MEA can regulate the LCST to 35 DEG C, close to the human body, is expected to be applied in biomedical field.
【学位授予单位】：华东师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O648.17

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