层层“点击”反应制备超薄水凝胶膜

发布时间：2018-01-17 17:18

本文关键词：层层“点击”反应制备超薄水凝胶膜　出处：《浙江大学》2015年硕士论文　论文类型：学位论文

【摘要】：超薄水凝胶膜具有广阔的应用前景,比如传感、药物传递、以及材料表面功能化修饰等等,因此对于水凝胶膜的研究越来越受到重视。通常水凝胶薄膜是通过将凝胶前体旋涂到基底表面,再通过交联的方法得到的。这是一种常用的方法,但是它有很多局限性。比如,这种方法往往只适用于具有规则几何形状、表面平整的基底,同时这种方法也很难对薄膜的厚度在微米尺度以下进行有效控制。本课题利用一种简便的方法,结合了层层自组装技术和“点击”化学反应来制备超薄水凝胶膜。首先通过缩合聚合的方法分别合成了分子链上带有多个双键或多个巯基的水溶性聚酯凝胶前体,再将巯基化的基底交替浸渍在两种凝胶前体溶液中,利用连续的巯基／双键的“点击”反应制备水凝胶膜,这一过程在室温下就可以快速进行,无需催化剂和光照引发等辅助条件。通过紫外可见吸收光谱分析发现,利用这种“层层点击法”制备的水凝胶膜的吸收强度随着层数的增加而增强。同时,利用椭圆偏振光谱仪测得的水凝胶膜的厚度也随着层数的增加线性增长,每个双层平均增加2.8 nm。一系列的实验结果表明,这种方法可以很好地制备厚度为纳米级的水凝胶膜。本课题中合成了一系列的聚酯型凝胶前体,一类高分子链上含有多个双键,另一类高分子链上含有多个巯基,同时它们还具有其它功能基团。比如,将含有季铵盐组分的聚酯作为凝胶前体之一,所制备水凝胶膜对大肠杆菌和金黄色葡萄球菌都有良好的抑制作用,而且抗菌效果随着水凝胶膜的层数的增加而增强。同时,这种超薄水凝胶膜也具有良好的生物相容性,有望在生物医用领域得到应用。再如,将喜树碱作为一种模型药物键接到其中一种凝胶前体上,再通过层层“点击”反应,制备出载药的超薄水凝胶膜。实验结果表明,这种水凝胶膜不仅可以作为药物载体,还可以在生理条件下通过酯键的水解将药物缓慢释放出来。总之,将层层自组装技术与“点击”化学结合起来,集中了二者的优势,使这种“层层点击法”成为一种方便、有效的方法制备超薄水凝胶膜,它具有非常广泛的应用前景。
[Abstract]:Ultrathin hydrogel films have broad application prospects, such as sensing, drug delivery, and the function of material surface modification and so on, so the research on hydrogel films have attracted more and more attention. Usually the hydrogel film by gel precursor spin coated onto the surface of the substrate, and then obtained by cross-linking method. This is a commonly used method however, it has many limitations. For example, this method is usually only applicable to with regular geometry, surface smooth, and this method is also very difficult for the film thickness in the micrometer scale under effective control. In this paper a simple method, combining the self-assembly technique and click chemistry reaction to prepare ultrathin hydrogel film. Firstly by condensation polymerization of the molecular chain were synthesized with a double bond or a plurality of sulfhydryl water-soluble polyester gel precursor, then captopril The base substrate immersed alternately in two kinds of gel precursor solution, using continuous thiol / double click reaction to prepare hydrogel film, this process can be quickly carried out at room temperature without catalyst and auxiliary conditions. Illumination caused by UV Vis absorption spectrum analysis showed that the use of the absorption intensity increased with the increase of layers at the click method "for the preparation of hydrogel membranes. At the same time, the use of hydrogel film ellipsometry measured the thickness of the linear growth with the increase of layers, each layer increased by an average of 2.8 nm. and a series of experimental results show that this method can better prepare thickness for nano hydrogel films. In this paper the synthesis of polyester gel precursor series, a kind of polymer chain containing more than one double bond, another polymer chain containing multiple thiols, at the same time it also has There are other functional groups. For example, containing polyester quaternary ammonium salt components as one of the gel precursors, the prepared hydrogel films have good inhibitory effect on Escherichia coli and Staphylococcus aureus, and the antibacterial effect increased with the increase of hydrogel film layers. At the same time, the ultrathin hydrogel film also has compatibility good life, is expected to be applied in the biomedical field. Moreover, the camptothecin as a model drug bonded to one gel precursor, and then through the layers of "click" reaction, preparation of ultrathin hydrogel film loaded. Experimental results show that the hydrogel membrane not only can be used as drug carrier, hydrolysis also through ester bonds under physiological conditions will slow drug release. In conclusion, the self-assembly technique combined with the "click" chemistry, focus on the advantages of the two kinds of the layers Clicking method is a convenient and effective method to prepare ultra-thin hydrogel membrane. It has a very wide application prospect.

【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：O648.17

【相似文献】