聚乙二醇基水凝胶及复合凝胶的制备与研究
发布时间：2019-03-21 16:03
【摘要】：聚乙二醇(PEG)含亲水链段,可以提高吸水性能。聚乙二醇基水凝胶具有良好的吸水保水性、生物相容性,可在人体内使用,不会引起炎症反应,而且能被机体迅速排出体外而不产生任何毒副作用。聚乙烯醇,是一种用途相当广泛的水溶性高分子聚合物。聚乙烯醇(PVA)具有很多优良的特性,例如有良好的成膜性和抗拉强度,耐冲击、绝缘性好、耐磨、强力粘接性和良好的平滑性。聚N-异丙基丙烯酰胺(PNIPAm)水凝胶是目前研究最多的温敏水凝胶,属于典型的热缩型水凝胶,其最低临界温度(LCST)在32 ℃接近人体温度。若调节聚合物骨架中的亲水组分和疏水组分,LCST还可以上下变动。本实验分为两个部分,第一部分,利用异氰酸酯基容易与羟基反应的特性,通过接枝共聚法,首先合成了端基为异氰酸酯基团(IPDI)的聚乙二醇(PEG)预聚物(PEG-IPDI),再将聚乙烯醇和预聚物反应,合成PEG-IPDI-PVA水凝胶。进一步加入锂藻土、蒙脱土纳米填料,探究纳米填料对PEG-IPDI-PVA水凝胶性能的影响。结果表明,随锂藻土的加入溶胀率明显提高,说明锂藻土的加入改善了水凝胶的内部结构和物理、化学性能。而在35 ℃到40 ℃时,溶胀率增长迅速,改善了此类材料的温敏性能。蒙脱土的加入可有效提高聚合物的机械性能。第二部分,以低分子量的聚乙二醇甲基丙烯酸酯(PEGMA)和N-异丙基丙烯酰胺(PNIPAm)为主要单体,亚甲基双丙烯酰胺(BIS)为交联剂,过硫酸钾(KPS)和四甲基乙二胺(TEMED)为引发剂,采用自由基共聚法成功合成了 P(NIPAm-PEGMA)水凝胶。并添加锂藻工作为增强剂制备了系列纳米杂化凝胶。对该系列凝胶研究表明,PEGMA和锂藻土的加入可以改变PNIPAm凝胶的内部结构和性能,能够改善凝胶的力学性能,也会影响水凝胶的温敏性。
[Abstract]:Polyethylene glycol (PEG) contains hydrophilic chain segment, which can improve the water absorption performance. Polyethylene glycol-based hydrogels have good water absorption and water retention, biocompatibility, can be used in human body, do not cause inflammation, and can be quickly expelled by the body without any toxic side effects. Polyvinyl alcohol is a widely used water-soluble polymer. Polyvinyl alcohol (PVA) has many excellent properties, such as good film forming and tensile strength, impact resistance, good insulation, wear resistance, strong adhesion and good smoothness. Poly (N-isopropylacrylamide) (PNIPAm) hydrogel is the most studied thermosensitive hydrogel at present. It belongs to the typical thermal shrinkage hydrogel, and its lowest critical temperature (LCST) is close to the human body temperature at 32 鈩，
本文编号：2445100
[Abstract]:Polyethylene glycol (PEG) contains hydrophilic chain segment, which can improve the water absorption performance. Polyethylene glycol-based hydrogels have good water absorption and water retention, biocompatibility, can be used in human body, do not cause inflammation, and can be quickly expelled by the body without any toxic side effects. Polyvinyl alcohol is a widely used water-soluble polymer. Polyvinyl alcohol (PVA) has many excellent properties, such as good film forming and tensile strength, impact resistance, good insulation, wear resistance, strong adhesion and good smoothness. Poly (N-isopropylacrylamide) (PNIPAm) hydrogel is the most studied thermosensitive hydrogel at present. It belongs to the typical thermal shrinkage hydrogel, and its lowest critical temperature (LCST) is close to the human body temperature at 32 鈩，
本文编号：2445100
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