基于侧边抛磨光纤的表面等离子体共振折射率传感器
发布时间：2018-08-20 18:14
【摘要】：表面等离子体共振传感技术是近代物理学、化学、生物医学、环境科学等多学科高度交叉的新兴检测技术,具有无需标记、响应速度快、灵敏度高、分辨率高、抗电磁干扰能力强等优点,因而广泛应用于疾病诊断、食品安全、环境监测、药物筛查等检测领域。光纤SPR传感器体积轻巧、检测成本低、可进行远程在线监测,并易于复用及组网,代表了未来SPR传感系统便携化、网络化、在线远程监测的发展方向,成为近年来各国研究人员关注的热点。基于侧边抛磨光纤的SPR传感器具有结构简单、成本低、镀膜均匀性好、传感性能高等优势,是一种具有较大潜力可实用化的光纤SPR传感器。相对于研究报道较多的基于金膜的金-SPR传感器,基于银膜的银-SPR传感器性能更优而且成本较低。然而,银在环境中容易发生氧化、硫化等退化反应,银-SPR传感器的稳定性降低,其应用受到限制。本文将围绕高性能、低成本的银-侧边抛磨光纤SPR传感器,研究银-SPR光纤传感器的制备、优化及折射率传感响应特性,并对由银膜退化引起的传感器性能衰退进行定量研究。进一步地,文中通过表面自组装方法,采用氧化石墨烯对侧边抛磨光纤SPR传感器进行表面修饰,改善了银-SPR传感器的稳定性及折射率响应特性。本论文的主要工作包括如下内容:1)研究了侧边抛磨光纤的制备方法、参数优化及其传感响应性能。采用轮式机械光纤研磨法,基于普通单模光纤的精抛工艺,制作得到表面质量良好、器件参数精确可控的侧边抛磨光纤,为下一步SPR折射率传感器的研究与制备提供了光纤倏逝场基底。文中探索了快速研磨光纤的粗磨工艺,采用传输光谱在线监控系统精确控制光纤的抛磨进程,制作出表面带有大量平行划痕的粗磨侧边抛磨光纤。基于粗磨光纤传输光谱的FFT分析及表面形貌结构表征,提出了马赫-曾德干涉结构模型解释粗磨光纤的干涉现象,通过参数优化获得了干涉谐振峰对比度大于10 d B的粗磨侧边抛磨光纤,并对其温度、轴向应力、酒精气体浓度,以及液体折射率的传感响应特性进行了测试。2)在具有良好表面质量的侧边抛磨光纤上,采用真空热蒸镀法淀积了厚度为纳米量级的银膜,制备出银-侧边抛磨光纤SPR传感器,并对光纤的剩余厚度、抛磨长度、功率损耗银膜厚度等影响传感器性能的关键参数进行了实验优化。自行搭建了光纤SPR在线测试平台,测试了银-侧边抛磨光纤SPR传感器的折射率响应性能,通过灵敏度、谐振峰半高宽、分辨率、器件优化指标等参数对传感器的性能进行了分析讨论。作为本部分的创新点,文中对制约银-SPR传感器实际应用的传感性能退化问题进行了研究,分析了银-SPR传感器在空气、液体中由于银膜退化而引起的传感性能衰退,为银-SPR传感器的保存及使用提供了指导依据。3)针对改善银-SPR传感器的稳定性、折射率响应性能及自组装效率的需求,采用氧化石墨烯对银膜进行了表面自组装修饰,制作出基于氧化石墨烯的侧边抛磨光纤SPR折射率传感器。文中对氧化石墨烯溶胶的配制、氧化石墨烯薄膜的形貌表征、氧化石墨烯膜层自组装进程的在线监测进行了实验研究,并测试了寡层氧化石墨烯修饰后侧边抛磨光纤SPR传感器的折射率响应特性。基于氧化石墨烯的侧边抛磨光纤SPR传感器在稳定性、灵敏度以及对生物分子的自组装效率等方面有改善作用,为后续的生化检测提供了性能稳定、响应快速、灵敏度高、负载率高的光纤SPR折射率传感器基底。
[Abstract]:Surface plasmon resonance (SPR) sensing technology is a new and highly interdisciplinary detection technology in modern physics, chemistry, biomedicine, environmental science, etc. It has many advantages, such as no labeling, fast response, high sensitivity, high resolution, strong anti-electromagnetic interference ability and so on. So it is widely used in disease diagnosis, food safety, environmental monitoring, drug screening and so on. Optical fiber SPR sensor is light in size, low in cost, and can be used for remote on-line monitoring. It is easy to reuse and networking. It represents the future development direction of portable, networked and on-line remote monitoring of SPR sensor system, and has become the focus of attention of researchers all over the world in recent years. Silver-based SPR sensors have the advantages of simple structure, low cost, good uniformity of coating and high sensing performance. Compared with gold-based SPR sensors reported in more studies, silver-based SPR sensors have better performance and lower cost. However, silver is easily oxidized and vulcanized in the environment. The stability of the Ag-SPR sensor decreases and its application is limited by the degradation reaction. In this paper, the fabrication, optimization and response characteristics of the Ag-SPR fiber sensor are studied around the high-performance and low-cost Ag-Side Polished Fiber Optic SPR sensor. In order to improve the stability and refractive index response of the silver-SPR sensor, graphene oxide was used to modify the surface of the side-polished fiber SPR sensor by surface self-assembly method. A side polished fiber with good surface quality and precise controllable device parameters is fabricated by wheel-type mechanical fiber polishing method based on conventional single-mode fiber polishing technology. The fiber evanescent field substrate is provided for the further research and fabrication of SPR refractive index sensor. Based on the FFT analysis of the transmission spectrum and the characterization of the surface morphology, a Mach-Zehnder interferometric structure model is proposed to explain the interference phenomena of the roughly ground fiber. The temperature, axial stress, ethanol concentration and liquid refractive index of the roughly polished side-polished fiber with resonant peak contrast greater than 10 dB were measured. 2) Silver films with nanometer thickness were deposited on the side-polished fiber with good surface quality by vacuum hot-evaporation method. Optical fiber SPR sensor is edge polished, and the key parameters affecting the performance of the sensor, such as residual thickness, polishing length, power loss silver film thickness, are optimized experimentally. As an innovative point of this part, the degradation of the sensing performance of the silver-SPR sensor is studied. The degradation of the sensing performance of the silver-SPR sensor caused by the degradation of the silver film in air and liquid is analyzed. 3) In order to improve the stability, refractive index response and self-assembly efficiency of the silver-SPR sensor, graphene oxide was used to self-decorate the surface of the silver film, and a side-polished fiber SPR refractive index sensor based on graphene oxide was fabricated. The preparation of sol, morphology characterization of graphene oxide film and on-line monitoring of self-assembly process of graphene oxide film were studied. The refractive index response characteristics of side polished fiber SPR sensor modified with oligographene oxide were tested. The stability and sensitivity of side polished fiber SPR sensor based on graphene oxide were studied. It can also improve the self-assembly efficiency of biological molecules, and provide a stable, fast response, high sensitivity, high load rate optical fiber SPR refractive index sensor substrate for subsequent biochemical detection.
【学位授予单位】：深圳大学
【学位级别】：博士
【学位授予年份】：2016
【分类号】：TP212
[Abstract]:Surface plasmon resonance (SPR) sensing technology is a new and highly interdisciplinary detection technology in modern physics, chemistry, biomedicine, environmental science, etc. It has many advantages, such as no labeling, fast response, high sensitivity, high resolution, strong anti-electromagnetic interference ability and so on. So it is widely used in disease diagnosis, food safety, environmental monitoring, drug screening and so on. Optical fiber SPR sensor is light in size, low in cost, and can be used for remote on-line monitoring. It is easy to reuse and networking. It represents the future development direction of portable, networked and on-line remote monitoring of SPR sensor system, and has become the focus of attention of researchers all over the world in recent years. Silver-based SPR sensors have the advantages of simple structure, low cost, good uniformity of coating and high sensing performance. Compared with gold-based SPR sensors reported in more studies, silver-based SPR sensors have better performance and lower cost. However, silver is easily oxidized and vulcanized in the environment. The stability of the Ag-SPR sensor decreases and its application is limited by the degradation reaction. In this paper, the fabrication, optimization and response characteristics of the Ag-SPR fiber sensor are studied around the high-performance and low-cost Ag-Side Polished Fiber Optic SPR sensor. In order to improve the stability and refractive index response of the silver-SPR sensor, graphene oxide was used to modify the surface of the side-polished fiber SPR sensor by surface self-assembly method. A side polished fiber with good surface quality and precise controllable device parameters is fabricated by wheel-type mechanical fiber polishing method based on conventional single-mode fiber polishing technology. The fiber evanescent field substrate is provided for the further research and fabrication of SPR refractive index sensor. Based on the FFT analysis of the transmission spectrum and the characterization of the surface morphology, a Mach-Zehnder interferometric structure model is proposed to explain the interference phenomena of the roughly ground fiber. The temperature, axial stress, ethanol concentration and liquid refractive index of the roughly polished side-polished fiber with resonant peak contrast greater than 10 dB were measured. 2) Silver films with nanometer thickness were deposited on the side-polished fiber with good surface quality by vacuum hot-evaporation method. Optical fiber SPR sensor is edge polished, and the key parameters affecting the performance of the sensor, such as residual thickness, polishing length, power loss silver film thickness, are optimized experimentally. As an innovative point of this part, the degradation of the sensing performance of the silver-SPR sensor is studied. The degradation of the sensing performance of the silver-SPR sensor caused by the degradation of the silver film in air and liquid is analyzed. 3) In order to improve the stability, refractive index response and self-assembly efficiency of the silver-SPR sensor, graphene oxide was used to self-decorate the surface of the silver film, and a side-polished fiber SPR refractive index sensor based on graphene oxide was fabricated. The preparation of sol, morphology characterization of graphene oxide film and on-line monitoring of self-assembly process of graphene oxide film were studied. The refractive index response characteristics of side polished fiber SPR sensor modified with oligographene oxide were tested. The stability and sensitivity of side polished fiber SPR sensor based on graphene oxide were studied. It can also improve the self-assembly efficiency of biological molecules, and provide a stable, fast response, high sensitivity, high load rate optical fiber SPR refractive index sensor substrate for subsequent biochemical detection.
【学位授予单位】：深圳大学
【学位级别】：博士
【学位授予年份】：2016
【分类号】：TP212
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