基于因子分析与关联规则挖掘干眼症的用药规律

发布时间：2018-06-26 04:09

本文选题：因子分析 + 关联规则　；参考：《中华中医药杂志》2017年10期

【摘要】：目的:挖掘中医药治疗干眼症的组方用药规律。方法:以CNKI中公开发表的文献为基础,运用SPSS20.0与IBM SPSS Modeler 14.1软件为工具,对高频中药进行因子分析、关联规则分析,以找到治疗本病的方剂的最优共性规律,探索干眼症的用药规律。结果:干眼症的治疗方剂115首,使用频率在10%以上的中药共计30味,聚为6类,常用药物组合为菊花、麦冬、枸杞子、生地黄、茯苓、白芍、熟地黄、当归、牡丹皮、玄参、甘草、柴胡、石斛、山药等,干眼症治疗的药物四气以寒性居第1位,五味以甘味为第1位,归经以肝经、肾经为主,关联规则挖掘出药对17个、药队8个。结论:中医药治疗本病的药物的使用"四气"与"五味"以甘、寒类中药为主;药物归经主要集中于肝经与肾经,说明干眼症的治疗与两脏有关,亦可反推出本病病位与肝、肾两脏密切相关;因子分析与关联规则算法挖掘出的潜在药物组合、药对、药队,多针对本虚标实的病机,阐明"益气养阴,滋补肝肾,疏肝解郁,柔肝止痛,清肝明目,补血活血"是本病的根本治疗大法,且临床上病情变化多端,故须精准辨证,有针对性地选择用药,才能切中主题,提高干眼症的治疗效果。
[Abstract]:Objective: to explore the rule of prescribing medicine in the treatment of xerophthalmia with traditional Chinese medicine (TCM). Methods: based on the published literature in CNKI and using SPSS 20.0 and IBM SPSS Modeler 14.1 software, factor analysis and association rule analysis of high frequency Chinese medicine were carried out in order to find the best common law of the prescription for treating this disease. To explore the rule of drug use of dry eye. Results: 115 prescriptions of dry eye syndrome were used with 30 kinds of traditional Chinese medicine with frequency of more than 10%, which were divided into 6 categories. The commonly used drugs were chrysanthemum, Ophiopogonis ophiopogonis, Fructus Lycii, Radix Rehmanniae Rehmanniae, Poria cocos, Radix Paeoniae Alba, Radix Rehmanniae Rehmanniae, Angelica sinensis, Peony Licorice, Radix Bupleurum, Dendrobium, Dioscorea yam and so on. The drugs for dry eye disease were cold in first place, sweet taste in the first place, liver meridian and kidney meridian as the main meridians, association rules excavating 17 drugs for 17, and drug teams for 8. Conclusion: the use of "four qi" and "five flavors" in traditional Chinese medicine for the treatment of this disease is mainly composed of Gan and cold herbs, and the drug meridian is mainly concentrated on the liver and kidney meridians, indicating that the treatment of dry eye disease is related to the two viscera, and it can also be used to deduce the location of the disease and the liver. Factor analysis and association rule algorithm excavate potential drug combinations, drug pairs, drug teams, most of which are aimed at the pathogenesis of this deficiency and reality, to clarify "replenishing qi and nourishing yin, nourishing liver and kidney, soothing the liver and relieving depression, softening the liver and relieving pain, and clearing the liver and the eyes," Tonifying blood and promoting blood circulation "is the basic treatment method of this disease, and the disease changes in clinic, so we must accurately differentiate the symptoms and signs, and choose the medicine pertinently, so we can get to the theme and improve the therapeutic effect of dry eye disease."
【作者单位】：上海中医药大学附属普陀医院;
【基金】：上海市医学重点专科——眼科(No.ZK2015A20) 上海中医药大学预算内项目(No.2015YSN50) 上海市普陀区卫生系统自主创新科研项目——重大项目(No.2015PTKW001)~~
【分类号】：G353.1;R276.7

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