WONCA研究论文摘要汇编——癌症诊断对自杀及心血管疾病死亡发生率的影响

发布时间：2018-01-12 14:00

  本文关键词：WONCA研究论文摘要汇编——癌症诊断对自杀及心血管疾病死亡发生率的影响　出处：《中国全科医学》2013年11期 　论文类型：期刊论文

  更多相关文章： WONCA 研究论文 摘要 汇编 癌症 诊断 自杀 血管疾病 死亡 发生率 影响

【摘要】：背景收到癌症诊断对患者来讲是一种创伤性经历,其直接导致的不良健康后果可超过疾病或治疗产生的影响。方法我们利用泊松及负二项回归模型,进行一项含有6 073 240例瑞典人的历史性队列研究,以探究癌症诊断与1991—2006年期间自杀或心血管疾病死亡直接风险的关系。为了校正无法测定的混杂因素,对队列中因自杀或心血管疾病死亡的癌症患者进行巢式、自我匹配的病例交叉分析。结果与未患癌症的受试者相比,收到癌症诊断的患者在第1周内的自杀相对风险为12.6,95%CI(8.6,17.8)(29例患者,发生率为2.5例/1 000人年);第1年内为3.1,95%CI(2.7,3.5)(260例患者,发生率为0.6例/1 000人年)。诊断后第1周内的心血管疾病死亡相对风险为5.6,95%CI(5.2,5.9)(1 318例患者,发生率为116.80例/1 000人年);前4周内为3.3,95%CI(3.1,3.4)(2 641例患者,发生率为65.81例/1 000人年)。诊断后第1年内,升高的风险迅速降低。对于预后不良的癌症,风险的增加尤其明显。病例交叉分析很大程度上证实了先前主要分析得出的结果。结论本次大规模队列研究中,新近收到癌症诊断的患者与未患癌症的受试者相比,自杀及心血管疾病死亡风险均有所增加。
[Abstract]:Background receipt of cancer diagnosis was a traumatic experience for patients with a direct result of adverse health consequences beyond the effects of disease or treatment . Methods We performed a historical cohort study of 6 073 240 Swedes using Poisson and negative binomial regression models to investigate cancer diagnosis with a nested , self - matched case cross - analysis for cancer patients who died of suicide or cardiovascular disease during the first week ( 29 patients , 2.5 / 1,000 years ) ; and 3.1 , 95 % CI ( 2.7 , 3.5 ) in the first year ( 260 patients with an incidence of 0.6 / 1,000 ) . The relative risk of cardiovascular disease deaths within the first week after diagnosis was 5.6 , 95 % CI ( 5.2 , 5.9 ) ( 1,318 patients , incidence rate 116 . 80 / 1,000 person years ) ; 3.3 , 95 % CI ( 3.1 , 3.4 ) in the first 4 weeks ( 2,641 patients , incidence : 65.81 / 1,000 person years ) . The increased risk was rapidly reduced within the first year of diagnosis . The increased risk was particularly evident for poor prognosis . The case - crossover analysis largely confirmed the results of the previous primary analysis . Conclusion In this large cohort study , there has been an increase in the risk of suicide and cardiovascular death in patients with newly received cancer diagnosis compared to those without cancer .

【作者单位】： 中国石油天然气集团公司中心医院;
【分类号】：R730.4
【正文快照】： 原文见:Fang F,Fall K,Mittleman MA,et al.Suicide and cardiovascular death after a cancer diagnosis[J].N Engl J Med,2012,366(3):1310-1318.published at http://www.nejm.org/doi/full/10.1056/NEJMoa1110307.WONCA研究论文摘要汇编——癌症诊断对自杀及心血管疾病死，

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