Nature Genetics ：发现鸭对禽流感产生免疫反应的基因

  本文关键词：Nature Genetics，，由笔耕文化传播整理发布。

关键词：禽流感,鸭

近日，《自然—遗传学》期刊发表了鸭基因组的全序列，并找出令鸭子对禽流感产生免疫反应的遗传基因。此一发现将有助科学家进一步了解水禽的免疫保护机制。

最近出现的H5N1亚型禽流感病毒已在家禽中广泛散布，而鸭子更被视为此病毒的天然宿主。早期的研究显示，鸭子能在毫无症状的情况下传播流感病毒。

李宁和他的研究团队为一只来自北京的雌性鸭子作出了基因测序。与其他鸟类和哺乳动物的基因组相比，鸭子的基因组所包含的免疫基因明显较少，数量与鸡和斑胸草雀的基因组相似。作者比较了受高致病性和低致病性H5N1病毒感染的鸭子，发现其肺部组织的基因表达会因病毒感染而有所改变。他们还确认了那些遗传因素能令鸭子成为禽流感病毒的天然宿主，例如鸟类和哺乳动物的β-防御素。（生物谷Bioon.com）

生物谷推荐英文摘要：

Nature Genetics     doi:10.1038/ng.2657

The duck genome and transcriptome provide insight into an avian influenza virus reservoir species

Yinhua Huang, Yingrui Li, David W Burt, Hualan Chen, Yong Zhang, Wubin Qian, Heebal Kim, Shangquan Gan, Yiqiang Zhao, Jianwen Li, Kang Yi, Huapeng Feng, Pengyang Zhu, Bo Li, Qiuyue Liu, Suan Fairley, Katharine E Magor, Zhenlin Du, Xiaoxiang Hu, Laurie Goodman, Hakim Tafer, Alain Vignal, Taeheon Lee, Kyu-Won Kim, Zheya Sheng

The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.

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  本文关键词：Nature Genetics，由笔耕文化传播整理发布。