松弛素在放射性肺损伤模型中的表达和作用

发布时间：2017-12-26 17:38

本文关键词：松弛素在放射性肺损伤模型中的表达和作用　出处：《临床肺科杂志》2016年08期 　论文类型：期刊论文

【摘要】：目的动态观察放射性肺损伤大鼠模型及松弛素的表达和作用,寻求防治放射性肺损伤的新途径。方法 72只大鼠随机分为对照组和照射组,照射组可分为单纯照射组和松弛素组。照射组第0天25Gy全肺照射,松弛素组第42天起应用松弛素治疗,第1、7、14、28、35、42、49、56天终止实验,肺组织行病理学观察、羟脯氨酸含量及松弛素基因水平表达的测定。结果与对照组相比,照射组松弛素mRNA表达升高,呈现先上升后下降的趋势,照射组第42天出现明显的肺纤维化,应用松弛素治疗后,胶原沉积减少,松弛素组的松弛素mRNA表达较单纯照射组显著升高,差异有统计学意义(P0.05)。结论松弛素与放射性肺损伤的发生、发展有很大的关系,并能改善已形成的肺纤维化。
[Abstract]:Objective to dynamically observe the expression and effect of the rat model of radionuclide injury and relaxin in order to find a new way to prevent and cure radioactive lung injury. Methods 72 rats were randomly divided into the control group and the irradiated group. The irradiated group could be divided into the simple irradiation group and the relaxin group. On the zeroth day, the 25Gy group was given whole lung irradiation. The relaxin group was treated with relaxin for forty-second days, and first, seventh, fourteenth, 28, 35, 42, 49 and 56 days. The lung tissue was examined by pathology, hydroxyproline content and relaxin gene expression. Results compared with the control group, irradiation group cytochalasin mRNA expression increased, showed a downward trend after rising for forty-second days, the irradiation group appeared obvious application of pulmonary fibrosis, relaxin treatment, reduced collagen deposition, relaxation of relaxin group mRNA expression compared with the irradiation group increased significantly, the difference was statistically significant (P0.05). Conclusion relaxin has a great relationship with the occurrence and development of radionuclide injury, and can improve the pulmonary fibrosis that has been formed.
【作者单位】：佳木斯大学附属第一医院呼吸内科;
【基金】：黑龙江省教育厅科学技术研究项目(No 12541817)
【分类号】：R563;R-332
【正文快照】： 课题来源:黑龙江省教育厅科学技术研究项目(No 12541817)在我们对机体行放射治疗胸部肿瘤,如乳腺癌、食道癌、肺癌的同时,肺组织往往会不可避免地遭受一定程度的损伤,称之为放射性肺损伤[1]。临床上有两种表现形式,通常把发生在放疗后1-6个月期间的称之为放射性肺炎,6个月之后

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