无菌鼠模型在结直肠癌研究中的应用

发布时间：2017-12-27 14:43

本文关键词：无菌鼠模型在结直肠癌研究中的应用　出处：《中国实验动物学报》2017年06期 　论文类型：期刊论文

【摘要】：越来越多的证据表明,肠道微生物群的组成与结直肠癌的发生发展密切相关。无菌动物模型,尤其是无菌鼠模型简单、易获得,为研究微生物群、结直肠肿瘤及机体间的复杂关系提供了重要工具。无菌鼠模型的建立主要通过剖腹产及无菌隔离器饲养和繁育来实现。在此基础之上,可以根据特定的研究目的,建立转基因或药物诱导的特殊类型无菌鼠模型。目前,无菌鼠模型在结直肠癌研究中已经得到了广泛应用。基于无菌鼠模型的研究结果表明,微生物或微生物群可以激活免疫和诱发炎症,从而促进结直肠癌的发生发展;同时也证明,微生态失衡与结直肠癌的发生发展相辅相成、互为因果关系。由于无菌鼠模型是研究微生态失衡所致的结直肠癌及相关疾病研究重要且有效的研究载体,因此,值得进一步推广应用。
[Abstract]:More and more evidence suggests that the composition of the intestinal microflora is closely related to the development of colorectal cancer. Aseptic animal models, especially the sterile mouse models, are simple and easy to obtain. They provide an important tool for studying the complex relationships between microbial communities, colorectal tumors and organisms. The establishment of the aseptic rat model is mainly realized by caesarean section and the breeding and breeding of the aseptic isolator. On this basis, a special type of transgenic or drug-induced aseptic rat model can be established on the basis of specific research purposes. At present, the aseptic rat model has been widely used in the study of colorectal cancer. The research results based on the germ free mouse model show that microbes or microbes can activate immunity and induce inflammation, thereby promoting the occurrence and development of colorectal cancer. At the same time, it is also proved that microecological imbalance is complementary to each other and has a causal relationship with the occurrence and development of colorectal cancer. Because the sterile mouse model is an important and effective research carrier for the research of colorectal cancer and related diseases caused by microecological imbalance, it is worthy of further promotion and application.
【作者单位】：香港中文大学内科与药物治疗学系消化病学研究所香港中文大学消化疾病研究国家重点实验室;
【基金】：国家973计划(No.2013CB531401)
【分类号】：R-332;R735.34
【正文快照】： junyu@cuhk.edu.hk在世界范围内,结直肠癌是男性第三、女性第二常见的恶性肿瘤,其在发达地区(澳大利亚、新西兰、欧洲和北美洲)的发病率显著高于不发达地区(非洲和中南亚)[1]。在中国,结直肠癌的发病率和死亡率分别约为376.3/10万和191.0/10万,且城市明显高于农村;而在香港,结

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