经颅交流电刺激对心理旋转认知过程的影响

发布时间：2018-01-04 23:09

本文关键词：经颅交流电刺激对心理旋转认知过程的影响　出处：《中国生物医学工程学报》2017年05期 　论文类型：期刊论文

【摘要】：经颅交流电刺激(tACS)是一种通过在头皮施加微弱交流电刺激、从而进行神经调节的非侵入刺激技术,已经被证实可以调节大脑的认知功能。心理旋转是一种想像客体或自身旋转的空间表征转换能力,是衡量空间认知能力的重要标尺之一。探索tACS对心理旋转认知能力的影响,利用心理旋转实验范式,以行为学表现和ERP、ERD等电生理参数作为主要评判指标,分析tACS对心理旋转产生的作用。行为学结果表明,alpha节律的tACS可以显著减少反映时间(P0.05),并且反映时随着刺激图片旋转角度的增加先增大后减小。比较对照组和8~12 Hz刺激组的心理旋转相关的负波(RRN),发现刺激组的RRN幅值比对照组幅值低(刺激组vs对照组,P0.05),同时发现RRN幅值随着刺激图片旋转角度的增加呈现先降低后升高的趋势。时频分析结果显示,刺激组的alpha和beta频段的事件相关去同步(ERD)现象比对照组更弱(刺激组vs对照组,P0.05),且ERD开始时间更早。有研究表明,ERD强弱与大脑激活水平有关,说明tACS作用后,大脑激活水平降低;进而提示tACS可以提高被试的心理旋转能力,有望成为提高空间认知能力的新途径。
[Abstract]:Transcranial alternating current (TAC) stimulation is a non-invasive stimulation technique by applying weak AC stimulation to the scalp to regulate the nerves. It has been shown to regulate the cognitive function of the brain. Mental rotation is the ability to visualize the spatial representation of the object or of its own rotation. It is one of the important scales to measure spatial cognitive ability. To explore the influence of tACS on mental rotation cognitive ability, to use the mental rotation experimental paradigm, behavioral performance and ERP. The effect of ERD on mental rotation was analyzed by using ERD isoelectric physiological parameters as the main evaluation index. The behavioral results showed that the effect of tACS on mental rotation. The tACS of alpha rhythm can significantly reduce the response time (P0.05). And the response time increased firstly and then decreased with the increase of the rotation angle of the stimulus image. The negative wave RRN related to mental rotation in the control group and the 8Hz 12 Hz stimulation group were compared. It was found that the amplitude of RRN in the stimulation group was lower than that in the control group (stimulation group vs control group P 0.05). At the same time, it was found that the amplitude of RRN decreased first and then increased with the increase of the rotation angle of the stimulus image. The results of time-frequency analysis showed that the amplitude of RRN decreased firstly and then increased. The event-related desynchronization of alpha and beta in the stimulation group was weaker than that in the control group (P 0.05). Some studies have shown that the intensity of ERD is related to the level of brain activation, which indicates that the level of brain activation decreases after the action of tACS. The results suggest that tACS can improve the mental rotation ability of the subjects and may be a new way to improve the spatial cognitive ability.
【作者单位】：河北工业大学电气工程学院生物医学工程系;清华大学工程物理系;中国医学科学院北京协和医学院生物医学工程研究所;
【分类号】：R338;TN911.7
【正文快照】： 3(中国医学科学院北京协和医学院生物医学工程研究所,天津300192)引言经颅交流电刺激(transcranial alternating currentstimulation,t ACS)是通过在头皮上施加微弱交流电,以达到刺激颅内中枢神经目的的一种非侵入式刺激技术[1]。目前对于t ACS的研究多集中在对认知能力的影响

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