运脾消食颗粒对厌食症大鼠模型胃窦部胃泌素和血清八肽胆囊收缩素调节作用的研究

发布时间：2018-01-10 08:18

本文关键词：运脾消食颗粒对厌食症大鼠模型胃窦部胃泌素和血清八肽胆囊收缩素调节作用的研究　出处：《中华中医药学刊》2016年01期 　论文类型：期刊论文

【摘要】：目的:探讨运脾消食颗粒对厌食症大鼠模型胃泌素(gastrin)、八肽胆囊收缩素(CCK-8)含量的影响。方法:采用病因模拟法建立小儿厌食症动物模型,分别对模型大鼠摄食量、体质量以及gastrin、CCK-8含量进行检测。结果:运脾消食颗粒可以明显增强厌食症大鼠的食欲,增加体质量,提高胃窦部gastrin含量,降低血清CCK-8含量,与模型对照组比较,差异均有统计学意义(P0.05或P0.01)。结论:运脾消食颗粒对厌食症模型具有明显治疗作用。其发挥临床疗效的作用机制可能是通过调节gastrin、CCK-8含量实现的。
[Abstract]:Objective: To investigate the effect of Yunpi Xiaoshi granules on gastrin anorexia rat model (gastrin), eight (CCK-8) octapeptide content. Methods: the etiology of infantile anorexia animal model establishment and simulation method, respectively, in a rat model of food intake, body weight and gastrin, CCK-8 were detected. Results: the spleen digestion the particles can significantly enhance anorexia rats appetite, increased body weight, increase the content of gastrin in gastric antrum, reduce serum CCK-8 content, compared with the model group, the differences were statistically significant (P0.05 or P0.01). Conclusion: Yunpi Xiaoshi granules has obvious therapeutic effect on anorexia model. Its clinical efficacy the mechanism may be through the regulation of gastrin, CCK-8 content.

【作者单位】：河北联合大学中医学院;
【基金】：河北省中医药管理局指令项目(2014054) 唐山市科技局指导项目(13130216b)
【分类号】：R285.5;R-332
【正文快照】： 厌食症是临床中常见的小儿消化系统疾病,表现为非疾病因素而出现较长时期的见食不贪、食欲不振、甚则拒食,多见于1~6岁的儿童,城市发病率高于农村,一年四季均可发病,尤以夏末秋初多见。厌食症对小儿的生长发育、营养状况、智力发展均有影响。长期厌食,可使小儿摄取营养物质不

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