桑白皮水煎总提物对脾虚水湿不化大鼠模型的影响

发布时间：2018-01-16 21:26

本文关键词：桑白皮水煎总提物对脾虚水湿不化大鼠模型的影响　出处：《中国新药杂志》2017年17期 　论文类型：期刊论文

【摘要】：目的:以单味中药白术和复方四君子汤为对照,研究桑白皮对脾虚水湿不化大鼠模型的影响,通过比较对同一模型的干预作用因归经不同表现出的作用差异和作用特点,为桑白皮归经的药性研究提供参考。方法:采用高脂低蛋白饮食加负重游泳复合因素法建立脾虚水湿不化大鼠模型,以一般状况、自主活动、胃排空率、小肠推进率、尿D-木糖排泄率、血清胃泌素(GAS)、IL~(-1)、IL-2、Ig-G、血浆生长抑素(SS)、P物质(SP)、血管活性肠肽(VIP)、脾脏系数、水负荷指数等为检测指标,考察桑白皮对脾虚水湿不化大鼠模型的影响。结果:给药后,桑白皮、白术及四君子汤均显著升高胃排空率、D-木糖排泄率、血清GAS、Ig-G、IL~(-1)、IL-2、血浆SP水平、脾脏系数(P0.05或P0.01),显著降低血浆SS和VIP水平(P0.05或P0.01),其中四君子汤组作用最显著,白术次之;桑白皮和四君子汤显著增加大鼠尿量,显著降低水负荷指数(P0.05或P0.01);白术和四君子汤显著降低大鼠一般状况评分,显著升高小肠推进率(P0.05)。结论:归脾、胃经的白术显著改善脾虚大鼠的胃肠功能,符合中医的归经理论,但不及四君子汤,说明复方中各药物相互协同作用,提高疗效。桑白皮对脾虚大鼠胃肠功能有一定的改善作用,其作用机制可能是调节血液中紊乱的胃肠激素趋于正常水平,桑白皮亦能增强免疫功能,与本草记载的桑白皮"归脾、肺经","味甘""补虚益气"性能功效相关。
[Abstract]:Objective: to single herb and compound Atractylodes Decoction of four noble drugs as control of cortex mori on spleen deficiency wet effect of rat model, through the comparison of the same model for intervention go through different show the difference and characteristics, provide reference for Sangbaipi to study the resistance method. The high fat and low protein diet plus swimming composite factor method to establish spleen deficiency rat model of water is not, in general condition, locomotor activity, gastric emptying rate, intestinal propulsive rate, urinary D- excretion rate, serum gastrin (GAS), IL~ (-1), IL-2, Ig-G, plasma somatostatin (SS), substance P (SP), vasoactive intestinal peptide (VIP), spleen coefficient, water load index as detection index of mulberry bark on spleen deficiency wet of rat model. Results: after administration, Morus alba, Rhizoma Atractylodis Macrocephalae and four gentleman Tang Junxian increased the rate of gastric emptying, D- excretion rate of serum GAS, Ig -G, IL~ (-1), IL-2, plasma SP levels, spleen coefficient (P0.05 or P0.01), significantly decreased plasma SS and VIP levels (P0.05 or P0.01), of which Four Gentlemen Decoction had the most significant effect, the mulberry bark and Atractylodes; four gentleman Decoction significantly increase the urine volume of the rats, significantly reduce the negative water load index (P0.05 or P0.01); and Baizhu Decoction of four noble drugs significantly reduce the scores of the general condition of rats increased significantly, intestinal propulsive rate (P0.05). Conclusion: the spleen, stomach Atractylodes significantly improve spleen deficiency rats with gastrointestinal function, TCM Meridian theory, but less than four of that in the Sijunzi Decoction, compound drugs the synergistic effect, improve the curative effect. Sangbaipi have certain effect on gastrointestinal function of spleen deficiency rats, its mechanism may regulate blood disorder of gastrointestinal hormone to the normal level, Sangbaipi can enhance immune function, and Materia Medica of Sangbaipi "spleen, lung", "sweet" and "tonic The performance effect of Qi supplementing is related.

【作者单位】：河南中医药大学;呼吸疾病诊疗与新药研发河南省协同创新中心;
【基金】：国家重点基础研究发展计划(973计划)资助项目(2013CB531802)
【分类号】：R285.5;R-332
【正文快照】： 桑白皮为桑科植物桑Morus alba L.的干燥根皮,性寒味甘,归肺经,具有泻肺平喘、利水消肿的功效,用于治疗肺热喘咳,水肿胀满尿少,面目肌肤浮肿[1]。现代药理学研究表明,桑白皮具有免疫、抗炎等作用[2-3]。白术为菊科植物白术Atractylodesmacrocephala Koidz.的干燥根茎,性温,味

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