miR-1246在疾病上的研究进展

发布时间：2018-01-21 09:18

本文关键词： miR- 癌症唐氏综合症埃博拉病毒感染疾病　出处：《生物技术通报》2017年03期 　论文类型：期刊论文

【摘要】：miRNAs是一类具有转录调控功能的小分子非编码RNA,参与了组织代谢和细胞增殖、分化、凋亡及基因表达,在许多生理和病理过程中扮演着重要的角色。目前,研发有效的miRNA激活剂或抑制剂来挽救和诊断病理状态,已成为医学研究领域的新方向和切入点。最新发现的miR-1246受P53调控,并与产生疾病的分子机制息息相关。综述了miR-1246序列结构特点及分子作用机制,对近年来miR-1246在癌症、埃博拉病毒传染病、唐氏综合症等疾病上的应用潜能进行了总结,并对该领域今后的发展前景作了展望,旨为医学研究提供理论参考。
[Abstract]:MiRNAs is a class of small molecule non-coding RNAs with transcriptional regulation, which is involved in tissue metabolism, cell proliferation, differentiation, apoptosis and gene expression. It plays an important role in many physiological and pathological processes. At present, effective miRNA activators or inhibitors have been developed to save and diagnose pathological state. It has become a new direction and entry point in the field of medical research. The newly discovered miR-1246 is regulated by p53. It is closely related to the molecular mechanism of disease. The structural characteristics of miR-1246 sequence and the molecular mechanism of its action are reviewed. In recent years, the molecular mechanism of miR-1246 in cancer and Ebola virus infectious diseases is reviewed. The application potential of Down syndrome and other diseases are summarized, and the future development prospect of this field is prospected, which is intended to provide a theoretical reference for medical research.
【作者单位】：西南大学荣昌校区动物科学系;
【基金】：重庆市科技支撑示范工程项目/丰都肉牛产业协同创新与关键技术攻关(jcsf121-2012-01-1) 中央高校基本业务费专项资金(XDJK2016E086) 西南大学荣昌校区青年基金(20700426)
【分类号】：R3416
【正文快照】： Mi RNAs是Lee等[1]在秀丽线虫中首次发现的一类长度约22个碱基、具有转录调节功能的非编码小RNA(non-coding RNA,nc RNA),其在各种生理和病理过程中扮演重要角色,如基因表达、细胞增殖、分化、凋亡、组织代谢和肿瘤生成等[2-4]。近年来已有大量的文章涉及了这方面的研究。迄今

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