含幽门螺杆菌特异性抗体牛奶清除幽门螺杆菌效果的临床随机试验

发布时间：2018-01-25 22:03

本文关键词： 幽门螺杆菌抗体牛奶临床随机试验　出处：《中国免疫学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的:比较观察抗幽门螺杆菌抗体牛奶根除幽门螺杆菌的效果。方法:用4株幽门螺杆菌(1株为标准菌株,3株为本地流行菌株)免疫奶牛,制备出抗幽门螺杆菌抗体牛奶。本次试验共筛选148例患者,C-14呼气试验阳性的患者为72例,最后符合入选标准的为39例,将符合标准的患者随机分为试验组和对照组,分别为21例和18例,试验组饮用含特异性幽门螺杆菌抗体的牛奶,对照组饮用普通牛奶,连续饮用2个月后,观察结果。结果:试验组的21名对象中,9人C-14呼气试验转为阴性,10人降低。有效清除率达42.86%,而对照组未有清除,两组清除率有统计学意义(P=0.005,P0.05)。结论:抗幽门螺杆菌抗体牛奶具有多克隆性和很高的效价,能够有效清除胃内幽门螺杆菌。
[Abstract]:Objective: to compare the efficacy of anti-Helicobacter pylori antibody milk in the eradication of Helicobacter pylori. Methods: dairy cows were immunized with 4 strains of Helicobacter pylori and 1 strain of Helicobacter pylori. Anti-Helicobacter pylori antibody milk was prepared. A total of 148 patients with positive C-14 breath test were screened in this study, and 39 patients met the inclusion criteria. The patients who met the standard were randomly divided into the experimental group (21 cases) and the control group (18 cases). The experimental group drank milk containing specific Helicobacter pylori antibody and the control group drank ordinary milk for 2 months. Results: among the 21 subjects in the trial group, 9 patients turned negative in C-14 breath test and 10 patients decreased. The effective clearance rate was 42.86, but the control group did not. Conclusion: the anti-Helicobacter pylori antibody milk has polyclonal and high titer and can effectively eliminate Helicobacter pylori in the stomach.
【作者单位】：河北医科大学第四医院科研中心;石家庄市疾控中心;河北医科大学临床学院;
【基金】：国家自然科学基金(81502032) 河北省中医药管理局研究项目(2015130) 河北省自然科学基金(H2015206376)项目资助
【分类号】：R392
【正文快照】： 1本文受国家自然科学基金(81502032)、河北省中医药管理局研究幽门螺杆菌(Helicobacter pylori,H.Pylori)是一种定植于人胃黏膜的微需氧革兰阴性杆菌。H.Py-lori感染属世界范围性,约有半数以上的人口胃内有H.Pylori定居。H.Pylori感染可引起慢性B型胃炎、消化性溃疡、胃黏膜相

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