结核分枝杆菌Ag85复合物疫苗研究进展

发布时间：2018-02-03 21:02

本文关键词： 结核病疫苗 Ag85复合物　出处：《重庆医科大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的:本文对Ag85复合物（Ag85complex,Ag85）在亚单位疫苗、重组疫苗和基因疫苗方面取得的成果进行综诉，希望能对国内结核领域的科研工作者起到一定的指导和借鉴意义。背景:目前全球结核病疫情呈上升趋势，而唯一使用的结核病疫苗—卡介苗的保护效力又有限，多耐药、泛耐药结核的产生和艾滋病的流行更使全球结核病的控制越来越困难，因此研发新的结核病疫苗迫在眉睫。Ag85复合物是MTB的一种重要的外分泌蛋白，能诱导实验动物产生细胞免疫和血清特异性抗体，增强其抗结核能力，在新疫苗研发领域备受关注。方法:复习文献，回顾分析Ag85复合物在亚单位疫苗、重组疫苗和基因疫苗方面的研究进展。结果:目前利用Ag85复合物在结核分枝杆菌(Mycobacteriumtuberculosis,MTB)感染中所具有的明显保护性效应为基础而研制的疫苗在结核病疫苗研究领域十分活跃，研究者们已经证实某些Ag85复合物疫苗的保护作用超过卡介苗(BacilleCalmette Guérin,BCG)；作为新疫苗给予新生儿、儿童和青少年接种是安全、有效的；作为加强免疫给予成人接种，可以提高机体抗结核能力；对已感染人群也具有增强细胞免疫、加速MTB清除的作用。结论:利用Ag85复合物的保护作用研发结核病新疫苗前景十分广阔，有几个疫苗已经进入临床实验阶段，，并有希望取代BCG。
[Abstract]:Objective: to summarize the achievements of Ag85 complex Ag85complexAg85 in subunit vaccine, recombinant vaccine and gene vaccine. It is hoped that it will provide guidance and reference to the domestic researchers in the field of tuberculosis. Background: the global TB epidemic is on the rise, and the only TB vaccine used, BCG, has limited protection and multidrug resistance. The emergence of pan-drug-resistant tuberculosis and the prevalence of AIDS make it more and more difficult to control tuberculosis worldwide. Therefore, the development of a new tuberculosis vaccine is imminent. Ag85 complex is an important exocrine protein of MTB. It can induce experimental animals to produce cellular immunity and serum-specific antibodies and enhance their antituberculous ability, which has attracted much attention in the field of new vaccine research and development. Methods: the research progress of Ag85 complex in subunit vaccine, recombinant vaccine and gene vaccine was reviewed. Results: Ag85 complex is currently used in Mycobacterium tuberculosis. The vaccine based on the obvious protective effect of MTB infection is very active in the field of tuberculosis vaccine research. Researchers have confirmed that some Ag85 complex vaccines are more protective than Bacillus Calmette Calmette Gu 茅 rindol BCG; It is safe and effective to vaccinate newborns, children and adolescents as new vaccines; As a strengthening of immunization to adults inoculation, can improve the body anti-tuberculosis ability; It can also enhance cellular immunity and accelerate the clearance of MTB in infected population. Conclusion: it is very promising to develop new TB vaccine by using the protective effect of Ag85 complex.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R392

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