微循环血流特征分析及其单元的模拟研究

发布时间：2018-02-15 20:24

本文关键词： 微循环代谢性调节微血管单元肠系膜灌流特征直捷通路　出处：《苏州大学》2011年硕士论文　论文类型：学位论文

【摘要】：微循环调节是循环系统能够统一调控和有序运行的基础,代谢性调节是微循环的主要调节方式之一。毛细血管是代谢性调节最末端的调节和功能性单元(毛细血管单元),是微循环调节实现的重要环节。但是当前毛细血管单元的原位检测手段比较缺乏,使得我们通过毛细血管单元来了解微循环动态变化特征时遇到困难。此外,微循环的主要功能是在毛细血管和组织细胞之间进行物质交换,微循环调控的精确机制还未得到阐明。因此,如何通过探索和阐明毛细血管结构及血流特征来了解和研究微循环的调控机制依然是一项值得关注的工作。本文依据在微循环代谢性调节理论方面方面提出的新的观点,主要针对如下两方面问题展开研究。第一,关注于微循环代谢性调节下的血流特征及其调控模式。利用青蛙肠系膜实验,对肠系膜微循环中的一些血流现象进行了描述,并通过分析对微循环的血流特征得到了一些新的认识。第二,通过制作模拟微循环单元的一些基础实验装置,对微循环的血流状况进行模拟研究,通过对实验中的血流灌注进行调节与改变,测量了微循环网络的流量,并通过对模拟微循环单元血流特征和实验数据的分析,探讨了微循环单元的结构与血流的关系、微循环单元的数量与血流的关系、各微循环单元之间血流的互动与关系、直捷通路的作用等问题,研究结果使得我们获得了对MVUs的运行模式及微循环调控机制的一些新理解。
[Abstract]:Microcirculation regulation is the basis for the unified regulation and orderly operation of the circulatory system. Metabolic regulation is one of the main regulation modes of microcirculation. Capillary is the terminal regulation and functional unit of metabolic regulation. The in-situ inspection of the tube unit is relatively lacking. That makes it difficult to understand the dynamic characteristics of microcirculation through capillary units. In addition, the main function of microcirculation is to exchange substances between capillaries and tissue cells. The precise mechanism of microcirculation regulation has not been elucidated. Therefore, how to understand and study the regulation mechanism of microcirculation by exploring and clarifying the capillary structure and blood flow characteristics is still a work worthy of attention. Based on the new viewpoint in the theory of microcirculatory metabolic regulation, this paper focuses on the following two aspects: first, Focusing on the characteristics of blood flow and its regulatory pattern under metabolic regulation of microcirculation, some blood flow phenomena in mesenteric microcirculation were described by frog mesenteric experiment. By analyzing the characteristics of blood flow of microcirculation, some new understandings are obtained. Secondly, the blood flow of microcirculation is simulated and studied by making some basic experimental devices for simulating microcirculation unit. The flow rate of microcirculation network was measured by adjusting and changing the blood perfusion in the experiment. The relationship between the structure of the microcirculation unit and the blood flow was discussed by analyzing the blood flow characteristics and experimental data of the simulated microcirculation unit. The relationship between the number of microcirculation units and blood flow, the interaction and relationship of blood flow among various microcirculation units, the role of direct pathway and so on. The results of this study have led us to obtain some new understanding of the operation mode of MVUs and the mechanism of microcirculation regulation.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R331

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