可变剪接调控因子SRSF2的研究进展

发布时间：2018-02-20 22:27

本文关键词： SRSF 可变剪接转录骨髓增生异常综合征遗传性疾病　出处：《生命的化学》2016年06期 　论文类型：期刊论文

【摘要】：RNA剪接是指从mRNA前体中去除内含子、连接外显子形成成熟mRNA的过程。由于选择不同的剪接位点,可变剪接控制着从单一前体mRNA生成多种成熟mRNA的过程,因此是真核生物中转录后调控基因表达和决定蛋白质多样性的重要层次。SR蛋白家族是参与调控可变剪接的一类重要的剪接因子。SRSF2是SR蛋白家族的一员,具有经典的SR蛋白结构域。SRSF2不仅能够调控可变剪接,还能调控基因的转录过程,在维持胸腺、骨髓等造血系统的正常发育以及维持肝脏代谢稳态中是非常关键的调控因子。大量的研究表明:SRSF2的突变与骨髓增生异常综合征等造血系统疾病密切相关。本文总结了SRSF2最近的研究进展,以期对SRSF2在体内的功能有更全面和深入的理解,并为相关疾病的研究和治疗提供一定的思路。
[Abstract]:RNA splicing is the process of removing introns from mRNA precursors and connecting exons to form mature mRNA. Due to the selection of different splicing sites, variable splicing controls the process of producing multiple mature mRNA from a single precursor mRNA. Therefore, SR protein family is one of the most important splicing factors involved in the regulation of variable splicing. SRSF2 is a member of SR protein family, which plays an important role in the regulation of gene expression and protein diversity in eukaryotes. The classical SR protein domain. SRSF2 can not only regulate the variable splicing, but also regulate the transcription process of the gene, which can maintain the thymus. The normal development of hematopoietic system such as bone marrow and maintaining the homeostasis of liver metabolism are very important regulatory factors. A large number of studies have shown that the mutation of 1: SRSF2 is closely related to hematopoietic diseases such as myelodysplastic syndrome. After concluding the recent research progress of SRSF2, In order to have a more comprehensive and in-depth understanding of the function of SRSF2 in vivo, and to provide some ideas for the research and treatment of related diseases.
【作者单位】：中国科学院上海生命科学研究院营养科学研究所;
【基金】：国家自然科学基金(31570818;31370786)
【分类号】：R3416

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