唑来膦酸对骨质疏松模型大鼠骨密度及骨代谢的影响

发布时间：2018-02-21 04:43

本文关键词： 唑来膦酸骨质疏松骨密度骨代谢　出处：《中国老年学杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的探讨唑来膦酸对骨质疏松模型大鼠骨密度及骨代谢的影响。方法将48只雌性SD大鼠按照随机数字法随机分为空白对照组、模型对照组、低剂量组(5 mg/kg)及高剂量组(10 mg/kg),每组12只。治疗结束12 w后,测定大鼠股骨骨密度、股骨抗弯力、子宫指数及双肾指数,检测血清骨钙素、1,25-二羟基维生素D3〔1,25(OH)2D3〕、血钙、血磷水平。结果与空白对照组比较,模型对照组及低剂量组大鼠骨密度、抗弯力、血清骨钙素、1,25(OH)2D3、血钙、子宫指数及双肾指数明显偏低(P0.05),而高剂量与空白对照组比较无统计学差异(P0.05);与模型对照组比较,低剂量组和高剂量组大鼠骨密度、抗弯力、血清骨钙素、1,25(OH)2D3、血钙、子宫指数及双肾指数明显偏高(P0.05);与低剂量组比较,高剂量组明显偏高(P0.05)。结论唑来膦酸10 mg/kg剂量能明显改善骨质疏松模型大鼠的骨密度及骨代谢水平,升高子宫及双肾指数,对骨质疏松模型大鼠具有较好的治疗效果。
[Abstract]:Objective to investigate the effects of zoledronic acid on bone mineral density and bone metabolism in osteoporosis model rats. Methods 48 female SD rats were randomly divided into control group and model control group. Low dose group (5 mg / kg) and high dose group (10 mg / kg), 12 rats in each group. After 12 weeks of treatment, bone mineral density (BMD), bending strength of femur, uterine index and double kidney index were measured, serum osteocalcin 125-dihydroxyvitamin D ~ (3 +) ~ (25) OH _ (2) D _ (3), serum calcium, and serum calcium were measured. Results compared with the blank control group, the bone mineral density (BMD), bending resistance, serum osteocalcin (OHH) 2D3 and serum calcium in the model control group and low dose group were higher than those in the control group. The uterine index and the double kidney index were significantly lower than that of the control group, but there was no significant difference between the high dose group and the blank control group (P 0.05), compared with the model control group, the bone mineral density (BMD), the bending resistance, the serum osteocalcin (BGP) of the rats in the low dose group and the high dose group, and the serum calcium content were higher than those in the control group. Compared with the low dose group, the uterine index and the double kidney index were significantly higher in the high dose group than in the low dose group. Conclusion the 10 mg/kg dose of zoledronic acid can improve the bone mineral density and bone metabolism, increase the index of uterus and kidney, and increase the index of uterus and kidney in the model rats with osteoporosis. It has good therapeutic effect on osteoporosis model rats.
【作者单位】：南阳市第一人民医院骨科;
【分类号】：R580;R-332

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