甘草对高脂血症大鼠模型洛伐他汀药代动力学的影响

发布时间：2018-03-02 03:11

  本文关键词： 洛伐他汀 洛伐他汀酸 甘草 药代动力学 高脂血症大鼠 药物相互作用　出处：《中国医科大学学报》2017年04期 　论文类型：期刊论文

【摘要】：目的研究高脂血症大鼠模型中甘草对洛伐他汀药代动力学过程的影响。方法将18只SD大鼠随机分为对照组(n=6)和实验组(n=12)。实验组采用高脂饲料喂养大鼠,构建高脂血症大鼠模型,随机分为洛伐他汀单独给药组(n=6)和洛伐他汀与甘草联合给药组(n=6)。联合给药组给予甘草颗粒,单独给药组给予相应体积的生理盐水,连续7 d后,2组大鼠单剂量灌胃给予洛伐他汀胶囊(20 mg/kg,0.5%CMC-Na溶液)。分别于给药前和给药后不同时间点采集血浆样品,采用液相色谱-质谱联用方法测定血药浓度,计算药代动力学参数,并进行组间比较。结果长期给予甘草导致洛伐他汀代谢产物洛伐他汀酸在高脂血症大鼠中血浆暴露水平显著升高,联合给药组平均C_(max)较单独给药组升高约80%(P0.05),而AUC0-t和AUC0-∞分别升高115%和109%(P=0.005和P=0.027)。联合给药组与单独给药组比较,洛伐他汀的C_(max)和AUC增加,但无统计学差异(P0.05)。结论甘草可抑制洛伐他汀在高脂血症大鼠体内的代谢,增加其体内暴露水平。
[Abstract]:Objective to study the effect of licorice on the pharmacokinetic process of lovastatin in hyperlipidemic rats. Methods Eighteen SD rats were randomly divided into two groups: control group (n = 18) and experimental group (n = 12). The experimental group was fed with hyperlipidemic diet to establish a hyperlipidemic rat model. The rats were randomly divided into two groups: lovastatin group (n = 6) and lovastatin / licorice group (n = 6). The combination group was given licorice granules, and the control group was given a corresponding volume of normal saline. After 7 days, two groups of rats were given lovastatin capsule 20 mg / kg and 0.5 CMC-Na solution by single dose. Plasma samples were collected at different time points before and after administration, and the plasma concentration was determined by liquid chromatography-mass spectrometry (LC-MS). Results Long-term administration of glycyrrhiza resulted in a significant increase in plasma exposure of lovastatin metabolite lovastatin in hyperlipidemic rats. Compared with the control group, the AUC0-t and AUC0- 鈭，

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