经颅霍尔效应刺激作用下神经元系统放电节律的理论研究

发布时间：2018-03-17 17:35

  本文选题：经颅霍尔效应刺激　切入点：Hodgkin-Huxley模型　出处：《中国生物医学工程学报》2016年02期 　论文类型：期刊论文

【摘要】：基于霍尔效应原理和Hodgkin-Huxley模型,研究经颅霍尔效应刺激对神经元系统放电节律的影响作用。研究表明,当超声和静磁场在神经元中产生的电流强度从10μA/cm2到55μA/cm2逐渐增大时,神经元动作电位的峰值从96 m V减小到71 m V,峰峰间期从15 ms减小到8.5 ms,发放率从4~6呈多级阶梯状逐渐增大。研究还发现,当超声的发射周期从6~100 ms逐渐增大时,神经元动作电位的发放率从1~5呈多级阶梯状逐渐增大。研究结果揭示经颅霍尔效应刺激对神经元放电节律的作用规律,有助于探索经颅霍尔效应刺激对神经精神类疾病治疗和康复的机理。
[Abstract]:Based on Hall effect principle and Hodgkin-Huxley model, the effects of transcranial Hall effect stimulation on the firing rhythm of neuronal system were studied. The results showed that the current intensity of ultrasound and magnetic field in neurons increased gradually from 10 渭 A / cm ~ 2 to 55 渭 A / cm ~ 2. The peak value of neuronal action potential decreased from 96 MV to 71 MV, the peak interval decreased from 15 Ms to 8.5 Ms, and the emitter rate gradually increased from 4 to 6. It was also found that when the emission period of ultrasound gradually increased from 6 Ms to 100 Ms, the peak value of action potential decreased from 96 MV to 71 MV, and the peak interval decreased from 15 Ms to 8.5 Ms. The firing rate of neuronal action potential increased gradually from 1 to 5. The results revealed the effect of transcranial Hall effect stimulation on the firing rhythm of neurons. It is helpful to explore the mechanism of transcranial Hall effect stimulation in the treatment and rehabilitation of neuropsychiatric diseases.
【作者单位】： 燕山大学电气工程学院;北京师范大学认知神经科学和学习国家重点实验室;
【基金】：国家自然科学基金(61503321) 河北省自然科学基金青年基金(F2014203161)
【分类号】：R338.8
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