功能性消化不良脾虚证大鼠模型的建立及评价

发布时间：2018-03-18 19:13

本文选题：功能性消化不良　切入点：脾虚症　出处：《中国实验动物学报》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨功能性消化不良脾虚证动物模型的建立及比较。方法分别采用碘乙酰以及复合小平台站立或复合游泳法建立功能性消化不良脾虚证大鼠模型,通过观察动物一般状态、体重及摄食量变化,检测血清胃动素、胆囊收缩素、乳酸、胃泌素的含量、尿D-木糖排泄率来评价成模效果。结果碘乙酰胺单因素组大鼠体重增长减缓、摄食量减少;复合因素组大鼠出现消瘦、毛发枯涩、腹泻等脾虚症状,且大鼠尿D-木糖排泄率、血清胃动素、胃泌素含量明显降低,而血清胆囊收缩素、乳酸含量明显升高。结论三种造模方法均能导致功能性消化不良脾虚症状,但复合因素处理组脾虚症状更明显,碘乙酰胺复合小平台站立法成模效果最佳。
[Abstract]:Objective to explore the establishment and comparison of the animal model of functional dyspepsia spleen deficiency syndrome. Methods the rat model of functional dyspepsia spleen deficiency syndrome was established by using the methods of iodine acetyl and combined small platform standing or swimming respectively, and the general state of the animal was observed. Changes of body weight and food intake, determination of serum motilin, cholecystokinin, lactic acid, gastrin and urinary D-xylose excretion rate were used to evaluate the model effect. In the compound factor group, spleen deficiency symptoms such as wasting, dry hair, diarrhea and so on were found, and the excretion rate of urine D-xylose, serum motilin and gastrin content were significantly decreased, while serum cholecystokinin was significantly decreased. Conclusion all the three methods can lead to the symptoms of spleen deficiency in functional dyspepsia, but the symptoms of spleen deficiency in the treatment group are more obvious, and the model effect is the best in the small platform station with iodoacetamide.
【作者单位】：湖南省药物安全评价研究中心新药药效与安全性评价湖南省重点实验室;湖南汉森医药研究有限公司;北京协和医学院药用植物研究所;
【基金】：湖湘青年创新人才基金
【分类号】：R259;R-332

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