宫腔注射无水乙醇对小鼠动情周期的影响

发布时间：2018-03-30 10:51

  本文选题：无水乙醇　切入点：宫腔注射　出处：《中国比较医学杂志》2017年05期

【摘要】：目的探讨宫腔内注射无水乙醇对小鼠动情周期的影响。方法利用阴道脱落细胞染色法选择动情期规律的小鼠20只,宫腔注射无水乙醇,术后第一个动情周期内每日测定其动情周期,随机择10只在第二个动情周期每2 h测一次,观察动情周期的改变程度。结果实验小鼠宫腔注射无水乙醇后动情周期整体发生大幅度延长,且动情期、动情前期等各期时间均发生了不同程度的紊乱。结论本实验通过观测无水乙醇损伤子宫后小鼠动情周期发生紊乱的现象,为临床无水乙醇的使用提供一定的实验基础。
[Abstract]:Objective to investigate the effect of intrauterine injection of anhydrous ethanol on estrous cycle in mice. Methods 20 mice with regular estrus period were selected by vaginal exfoliated cell staining and anhydrous ethanol was injected into uterine cavity. The estrus cycle was measured daily in the first estrus cycle after operation, and 10 were measured every 2 hours in the second estrus cycle. Results after injection of anhydrous alcohol into the uterus, the whole estrus cycle of mice was significantly prolonged, and the estrus period was also observed. Conclusion the disorder of estrus cycle in mice after anhydrous alcohol injury was observed in order to provide some experimental basis for clinical use of anhydrous ethanol.
【作者单位】： 山西医科大学实验动物中心实验动物与人类疾病动物模型山西省重点实验室;
【基金】：山西省实验动物资源共享服务平台建设(201605D121019) 山西省重点实验室建设项目(2015012001-09)
【分类号】：R-332
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本文编号：1685600