止痒乳膏对豚鼠变应性接触性湿疹模型皮损及组织形态学的影响

发布时间：2018-03-31 06:33

本文选题：止痒乳膏　切入点：特应性皮炎　出处：《中成药》2016年10期

【摘要】：目的观察止痒乳膏对豚鼠变应性接触性湿疹的抑制作用。方法采用2,4-二硝基氯苯(DNCB)建立豚鼠变应性接触性湿疹模型,以青鹏软膏为阳性对照,以基质乳膏为阴性对照,评价止痒乳膏对模型动物皮损及组织形态学改变的影响。结果经治疗两周,与模型组比,止痒乳膏大、中、小剂量组皮损症状评分及(病理组织学检查)炎性细胞计数明显降低,各治疗组的疗效指数均大于40%。与模型组比,止痒乳膏各组右耳肿胀值显著降低,且大剂量组与青鹏软膏组比较有显著性差异;病理组织学检查显示,止痒乳膏各组可不同程度使表皮完整性及角质松解程度减轻、真皮层炎性细胞浸润减少。止痒乳膏对以上各指标均显示出良好的量效关系,随剂量增加作用增强。结论止痒乳膏对豚鼠变应性接触性湿疹具有明显抑制作用,其疗效主要表现为抗炎、抗变态反应及减轻皮损。
[Abstract]:Objective to observe the inhibitory effect of Zhitao cream on allergic contact eczema in guinea pigs. Methods the allergic contact eczema model of guinea pigs was established by using DNCB2, Qingpeng ointment as positive control and matrix cream as negative control. Objective: to evaluate the effects of Zhiyang cream on skin lesions and histomorphologic changes in model animals. Results after two weeks of treatment, Zhiyang cream was larger and more moderate than the model group. The score of skin lesion symptom and the count of inflammatory cells in small dose group were significantly decreased, and the curative effect index of each treatment group was more than 40. Compared with the model group, the swelling value of right ear in each group was significantly lower than that in the model group. The histopathological examination showed that the epidermis integrity and keratinolysis could be alleviated in different degree by histopathological examination in large dose group and Qingpeng ointment group. There was a good dose-effect relationship between Zhiyang cream and the above indexes, which was enhanced with the increase of dose. Conclusion Zhiyang cream has obvious inhibitory effect on allergic contact eczema in guinea pigs. Its curative effect is mainly for anti-inflammation, anti-allergic reaction and reducing skin lesions.
【作者单位】：南京市中医院;南京中医药大学;
【基金】：南京市医学科技发展重点项目(ZKX13048) 南京市科技局科技发展计划(201308046)
【分类号】：R285.5;R-332

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