秀丽隐杆线虫衰老与衰老相关神经退行性疾病模型及药物筛选研究进展

发布时间：2018-04-05 14:06

本文选题：秀丽隐杆线虫　切入点：衰老　出处：《中国药理学与毒理学杂志》2017年05期

【摘要】：秀丽隐杆线虫(C.elegans)是生命科学领域非常重要的模式生物,具有寿命短、世代周期短、易于培养与观察等特点,因而被广泛用于生命科学研究,特别是在药物筛选和药物作用机制研究等方面。衰老是一个复杂的过程,是多因素共同作用的结果。在C.elegans中的抗衰老信号通路主要有3种,包括胰岛素-胰岛素样生长因子1信号通路、饮食限制信号通路和线粒体呼吸链/ATP合成信号通路。本文主要综述了基于以上3种信号通路的衰老模型以及基于以上衰老模型的抗衰老药物研究进展。此外,通过转基因或化学诱变可获得一些与衰老相关神经退行性疾病的C.elegans模型,包括帕金森病的α-突触核蛋白转基因模型、阿尔茨海默病的β-淀粉样蛋白沉积模型和亨廷顿舞蹈病的多聚谷氨酰胺聚集的转基因模型,总结了基于以上C.elegans疾病模型筛选的有效药物。正随着当今社会人口老龄化的日益加重,人口老龄化已对我国社会经济的稳定和发展产生了深远影响,与此同时与衰老相关的疾病也引起了人们的广泛关注,如何安全有效地延缓衰老已成为医学界和社会关注的焦点,因而衰老机制的探索以及抗衰老药物的研究已成为当今社会研究的一大热点。在衰老与抗衰老研究中人们遴选出了各种动物衰老模型,如D-半乳糖(D-galactose,D-Gal)所致的亚急性大鼠衰老模型[1]、β淀粉样蛋白(β-amyloid
[Abstract]:C. elegans is a very important model organism in the field of life science. It has the characteristics of short life span, short generation cycle, easy to cultivate and observe, so it is widely used in life science research.Especially in drug screening and drug action mechanism research and so on.Aging is a complex process and the result of multiple factors.There are three main anti-aging signaling pathways in C.elegans, including insulin-insulin-like growth factor 1 signaling pathway, diet restriction signaling pathway and mitochondrial respiratory chain / / ATP synthesis signal pathway.In this paper, the research progress of aging models based on the above three signaling pathways and anti-aging drugs based on the above aging models are reviewed.In addition, some C.elegans models of aging related neurodegenerative diseases can be obtained by transgenic or chemical mutagenesis, including the 伪 -synaptic nucleoprotein transgenic model of Parkinson's disease.The 尾 -amyloid deposition model of Alzheimer's disease and the transgenic model of polyglutamine accumulation in Huntington's disease were summarized. The effective drugs based on the above C.elegans disease model were summarized.With the increasing aggravation of the aging population, the aging of the population has had a profound impact on the social and economic stability and development of our country. At the same time, diseases related to aging have also aroused widespread concern.How to delay aging safely and effectively has become the focus of medical circles and society. Therefore, the exploration of aging mechanism and the research of anti-aging drugs have become a hot spot in the society.In the study of aging and anti-aging, various animal aging models, such as subacute aging model induced by D-galactoseD-Galal, 尾 -amyloid, were selected.
【作者单位】：山西大学中医药现代研究中心;山西大学化学化工学院;长治医学院基础医学院;
【基金】：山西省高等学校科技创新项目(2015119) 山西省科技创新重点团队(201605D131045-18) 山西省应用基础研究项目(201601D202058)~~
【分类号】：R-332;R741

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