秀丽隐杆线虫在抗衰老领域应用的研究进展

发布时间：2018-04-06 06:05

  本文选题：抗衰老　切入点：秀丽隐杆线虫　出处：《中国美容医学》2016年02期

【摘要】：秀丽隐杆线虫(Caenorhabditis elegans)是抗衰老研究中重要的模式生物之一,被广泛应用于抗衰老物质的筛选和抗衰老分子机制的研究中。本文回顾了近年来秀丽隐杆线虫在抗衰老领域应用的研究进展,介绍了抗衰老物质的筛选情况,系统综述了作为抗衰老物质筛选评价的生理指标和反映抗衰老机制的生化指标包括寿命、生存率、生存时间、ROS含量、脂褐质积累以及daf-16,sod-3,gst-4,hsps基因调控情况等,指出了研究中存在的问题,展望了秀丽隐杆线虫在抗衰老研究中的应用前景。
[Abstract]:Caenorhabditis eleanss (Caenorhabditis eleanss) is one of the most important model organisms in the study of anti-aging, and has been widely used in the screening of anti-aging substances and the study of anti-aging molecular mechanism.In this paper, the research progress of the application of Rhizoma elegans in the field of anti-aging in recent years was reviewed, and the screening of anti-aging substances was introduced.The physiological indexes, including life span, survival rate, Ros content, lipofuscin accumulation and the regulation of daf-16 sod-3gst-4hsps gene, were systematically reviewed as the physiological indexes for screening and evaluation of anti-aging substances and the biochemical indexes reflecting the anti-aging mechanism, such as life span, survival rate, Ros content, lipofuscin accumulation and daf-16 sod-3gst-4hsps gene regulation.The problems existed in the research were pointed out, and the application prospect of Steenostrongylus elegans in anti-aging research was prospected.
【作者单位】： 淮南联合大学医学系;淮南师范学院化学与材料工程学院;
【基金】：安徽省高校自然科学重点研究项目(KJ2015A349) 安徽省高校质量工程项目(2014jyxm472)
【分类号】：R339.38
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本文编号：1718276