低氧诱导因子对铁代谢的调节（英文）

发布时间：2018-04-09 21:10

本文选题：低氧诱导因子　切入点：铁代谢　出处：《生理学报》2017年05期

【摘要】：低氧诱导因子(hypoxia-inducible factors,HIFs)是一类介导细胞内低氧反应的核转录复合体。HIF-α和HIF-β形成有功能的异质二聚体。哺乳动物中有HIF-1α、HIF-2α和HIF-3α。HIFs在铁代谢中发挥重要作用。受HIFs调节的铁代谢相关蛋白主要有二价金属转运蛋白1(divalent metal transporter 1,DMT1)、铁转出蛋白(ferroportin 1,FPN1)、十二指肠铁细胞色素b(duodenal cytochrome b,Dcytb)和转铁蛋白受体(transferrin receptor,Tf R)。铁调素(hepcidin)和铁调节蛋白(iron regulatory proteins,IRPs)是调节机体与细胞内铁代谢、维持铁稳态的重要因子,同样受到HIFs的调节。本文综述了HIFs对上述铁代谢相关蛋白的调节作用,以期为治疗铁代谢相关疾病提供可能的靶点。
[Abstract]:Hypoxia-inducible factors (HIFs) are a kind of nuclear transcription complex. HIF- 伪 and HIF- 尾 form functional heterogeneous dimers.HIF-1 伪, HIF-2 伪 and HIF-3 伪. HIFs play an important role in iron metabolism in mammals.The iron metabolism-related proteins regulated by HIFs were mainly divalent metal transporter (1(divalent metal transporter 1), ferroportin 1 (FPN1), duodenal iron cytochrome b(duodenal cytochrome (Dcyt b) and transferrin receptor (TF).Iron heparin (hepcidin) and iron regulatory protein (IRP) are important factors in regulating iron metabolism and maintaining iron homeostasis in organism and cells, and are also regulated by HIFs.This paper reviews the regulatory effects of HIFs on iron metabolism-related proteins in order to provide possible targets for the treatment of iron metabolism-related diseases.
【作者单位】：青岛大学医学院生理学教研室山东省神经相关疾病重点实验室山东省神经退变疾病协同创新中心;
【基金】：supported by grants from the National Natural Science Foundation of China (No. 31571054, 81430024) the National Basic Research Development Program of China (No. 2011CB504102) Excellent Innovative Team of Shandong Province Taishan Scholars Construction Project,China
【分类号】：R33

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