脉康汤对内源性老年高脂血症模型大鼠血脂的影响

发布时间：2018-04-18 20:19

  本文选题：脉康汤 + 内源性高脂血症　； 参考：《中国老年学杂志》2017年07期

【摘要】：目的探讨脉康汤对内源性老年高脂血症大鼠模型血脂的影响。方法选用雄性Wistar大鼠40只,进行随机分为正常对照组、模型组、洛伐他汀组、脉康汤组,每组10只。采用给药L-蛋氨酸造模。造模成功后,各实验组分别给予相应药物灌胃治疗4 w,正常对照组给予蒸馏水。治疗结束取血检测大鼠的血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。结果病理组织切片表明脉康汤组脂肪变性改善,脂肪滴减少,炎症细胞浸润减轻。模型组大鼠血清TC、TG、LDL-C、载脂蛋白(Apo)B以及Lp(a)的水平显著高于脉康汤组、正常对照组、洛伐他汀组,而HDL-C、ApoAⅠ水平显著低于其他三组。与洛伐他汀组相比,脉康汤组大鼠血清TC、TG、ApoB、Lp(a)水平显著降低(P0.05),LDL-C、HDL-C、ApoAⅠ差异较小(P0.05)。脉康汤组极低密度脂蛋白胆固醇(VLDL-C)含量降低幅度明显大于洛伐他汀组(P0.05)。脉康汤组TC/HDL-C比值比洛伐他汀组的比值降低幅度较大(P0.05)。脉康汤组大鼠肝组织中超氧化物歧化酶(SOD)水平的上升幅度显著高于模型组(P0.05)。结论脉康汤对内源性高脂血症具有明显的调节作用。
[Abstract]:Objective to study the effect of mai Kang decoction on blood lipid in aged hyperlipidemia rats.Methods Forty male Wistar rats were randomly divided into normal control group, model group, lovastatin group and mai Kang decoction group with 10 rats in each group.The model was made by administration of L-methionine.After the model was successfully made, each experimental group was treated with corresponding drugs for 4 weeks, while the normal control group was given distilled water.Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were measured at the end of the treatment.Results the histopathological sections showed that the steatosis, the decrease of fat droplets and the infiltration of inflammatory cells were ameliorated in Maikang decoction group.The serum levels of TCU TGG LDL-C, apolipoprotein ApoA B and LPA in the model group were significantly higher than those in the mai Kang decoction group, normal control group, lovastatin group, and HDL-Cn ApoA 鈪，

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