microRNA与mRNA不同位点结合后的生物学效应研究进展

发布时间：2018-04-21 03:12

  本文选题：microRNA + mRNA　； 参考：《山东医药》2017年30期

【摘要】：microRNA(miRNA)是一类单链非编码小RNA,主要参与功能基因的转录后调控,具有广泛、多样的生物功能,在真核生物体内对基因表达具有重要的调控作用。miRNA既可以抑制编码基因mRNA的表达,又可以激活mRNA的作用;既可以在细胞质中作用于mRNA的不同区域,也可以返回细胞核中发挥重要的生物学功能;同一个miRNA不一定只是一种作用模式,它可以同时作用于3'UTR、5'UTR和ORF区域。在细胞质中,miRNA通过与mRNA 3个区域中存在的识别位点互补配对并结合一些辅助蛋白发挥作用;在细胞核中,miRNA通过与lncRNA的相互作用起到调节基因功能的作用;miRNA还可与DNA的启动子序列相结合,诱导基因转录与翻译。
[Abstract]:MicroRNAs miRNAs are a class of single-stranded non-coding small RNAs, which are mainly involved in the posttranscriptional regulation of functional genes, and have a wide range of biological functions. MiRNAs can inhibit the expression of the encoding gene mRNA in eukaryotic organisms. It can also activate the role of mRNA; it can act on different regions of mRNA in the cytoplasm, but also can return to the nucleus to play important biological functions. The same miRNA is not necessarily just a mode of action. It can act on both UTR and ORF region. In the cytoplasm, miRNAs work by complementing the recognition sites in the three regions of mRNA and binding to some coproteins. In the nucleus, miRNAs can regulate gene function by interacting with lncRNA, and can also bind to the promoter sequence of DNA to induce gene transcription and translation.
【作者单位】： 中国人民解放军第82医院;
【分类号】：R3416
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本文编号：1780672