贝伐珠单抗注射液在改善银屑病小鼠模型中的作用及机制

发布时间：2018-04-25 01:10

本文选题：银屑病 + 贝伐珠单抗注射液(安维汀)　；参考：《中国医院药学杂志》2017年14期

【摘要】：目的:研究贝伐珠单抗注射液(安维汀)在改善银屑病小鼠模型中所发挥的作用及作用机制。方法:通过对银屑病小鼠模型的构建,安维汀药物处理,小鼠病情等级评定,细胞因子检测,mRNA定量,蛋白免疫印迹的生物学方法,研究安维汀用药后,银屑病小鼠病情,体内细胞因子和血管生成因子mRNA含量及蛋白含量变化。结果:小鼠病情级别评定结果显示,安维汀能减轻银屑病的症状;mRNA定量结果和免疫蛋白印迹结果均显示,安维汀可以改变银屑病小鼠体内炎症细胞因子含量和血管生成因子含量,从而缓解银屑病的症状。结论:安维汀通过影响Th1类细胞因子IFN-γ,Th17类细胞因子IL-17A,Th2类细胞因子IL-4及Treg细胞因子IL-10及血管生成相关因子的含量,抑制炎症和血管的生成,从而改善银屑病症状。
[Abstract]:Aim: to study the role and mechanism of bevacizumab injection (AVP) in improving psoriatic model in mice. Methods: the model of psoriasis in mice was established, and the status of psoriasis mice was studied by the biological methods, such as the establishment of mice model of psoriasis, the treatment of antivenin, the evaluation of disease grade of mice, the quantification of cytokine mRNA, and the Western blotting. Changes of mRNA and protein contents of cytokines and angiogenic factors in vivo. Results: according to the evaluation of the severity of the disease in mice, both the quantitative results of mRNA and Western blotting showed that Anvitin could alleviate the symptoms of psoriasis. Anvitin can relieve the symptoms of psoriasis by changing the levels of inflammatory cytokines and angiogenic factors in psoriatic mice. Conclusion: Aventin inhibits inflammation and angiogenesis by affecting the levels of IL-4, Treg cytokines, IL-10 and angiogenesis related factors of Th1 cytokines IFN- 纬 and Th17, thus improving the symptoms of psoriasis.
【作者单位】：郑州市中医院;荥阳市中医院;郑州市中心医院;
【基金】：郑州市科技局科技发展项目(编号:20140443)
【分类号】：R-332;R758.63

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