狂犬病病毒糖蛋白生物学功能研究进展

发布时间：2018-04-26 22:24

本文选题：狂犬病 + 糖蛋白　；参考：《中国畜牧兽医》2016年12期

【摘要】：狂犬病是由狂犬病病毒(rabies virus,RABV)感染中枢神经系统引起的致死性人畜共患传染病。RABV糖蛋白存在于病毒表面,它既是病毒的主要保护性抗原,诱导体液免疫产生中和抗体和刺激T细胞产生细胞免疫,又是病毒与细胞受体结合的结构,在病毒致病性和嗜神经性中发挥重要作用,与病毒毒力直接相关。作者归纳总结国内外RABV糖蛋白结构与功能研究进展,并对糖蛋白中和抗体的检测与评价进行阐述。将为进一步揭示RABV糖蛋白生物学功能奠定基础,为糖蛋白中和抗体的诊断提供理论参考,为控制和消灭狂犬病做出相应贡献。
[Abstract]:Rabies is a fatal zoonotic infectious disease caused by rabies virus (rabies virus) infection in the central nervous system. RABV glycoprotein exists on the surface of the virus, and it is the main protective antigen of the virus. Inducing humoral immunity to produce neutralizing antibodies and stimulating T cells to produce cellular immunity is the structure of virus binding to cell receptor, which plays an important role in virulence and neuropathogenicity, and is directly related to virulence of virus. The structure and function of RABV glycoprotein were summarized, and the detection and evaluation of glycoprotein neutralizing antibody were described. It will lay a foundation for further revealing the biological function of RABV glycoprotein, provide a theoretical reference for the diagnosis of glycoprotein neutralizing antibody, and contribute to the control and elimination of rabies.
【作者单位】：中国农业科学院特产研究所特种经济动物分子生物学重点实验室;
【基金】：基金项目:宠物疫病快速诊断与疫苗研究与示范(3313022) 狂犬病病毒糖蛋白干预神经突触体递质释放循环功能的分子机制(31572505)
【分类号】：S852.65;R373.9

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